LHB

This gene is a member of the glycoprotein hormone beta chain family and encodes the beta subunit of luteinizing hormone (LH). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. LH is expressed in the pituitary gland and promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids. The genes for the beta chains of chorionic gonadotropin and for luteinizing hormone are contiguous on chromosome 19q13.3. Mutations in this gene are associated with hypogonadism which is characterized by infertility and pseudohermaphroditism. [provided by RefSeq, Jul 2008]

Description

Luteinizing hormone subunit beta

Tissue specificity

Tissue enriched (pituitary gland)

Subcell location

Cytosol

Predicted location

Secreted to blood

Protein family

Cancer-related genes
Disease related genes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted secreted proteins

Chromosome

19 (49015980 - 49017091)

Ensembl ID

ENSG00000104826  (ver. 103.38)

Orthologs

-

UniProt

P01229

neXtProt

NX_P01229

Human splice variants

Protein structure