18040-1-AP

antibody from Proteintech Group

Targeting: PTTG1 EAP1, HPTTG, PTTG, securin, TUTR1

ELISA (Data presented on provider website)

Immunocytochemistry (Supportive data in Antibodypedia)

Antibody Data

Product number

18040-1-AP

Provider

Proteintech Group

Proper citation

Proteintech Cat#18040-1-AP, RRID:AB_2173410

Product name

Securin / PTTG1 antibody

Antibody type

Polyclonal

Description

KD/KO validated Securin / PTTG1 antibody (Cat. #18040-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF,ELISA.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

Securin acetylation prevents precocious separase activation and premature sister chromatid separation.

Wang T, Zou Y, Meng H, Zheng P, Teng J, Huang N, Chen J
Current biology : CB 2024 Mar 25;34(6):1295-1308.e5

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Homozygous variants in CDC23 cause female infertility characterized by oocyte maturation defects.

Fan H, Zhou Z, Zheng W, Guan Y, Meng Q, Wang W, Dong J, Wan L, Zhu J, Zeng Y, Liu R, Gu H, Lin G, Chen B, Sang Q, Wang L
Human genetics 2023 Nov;142(11):1621-1631

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Phosphorylated PTTG1 switches its subcellular distribution and promotes β-catenin stabilization and subsequent transcription activity.

Zhang X, Wu N, Huang H, Li S, Liu S, Zhang R, Huang Y, Lyu H, Xiao S, Ali DW, Michalak M, Chen XZ, Zhou C, Tang J
Oncogene 2023 Aug;42(32):2439-2455

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Melatonin promotes in vitro maturation of vitrified-warmed mouse GV oocytes potentially by modulating MAD2 protein expression of SAC component through MTRs.

Yang J, Guo S, Pan B, Qazi IH, Qin J, Zang S, Han H, Meng Q, Zhou G
Cryobiology 2021 Oct;102:82-91

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The Pseudogene PTTG3P Promotes Cell Migration and Invasion in Esophageal Squamous Cell Carcinoma.

Zhang Z, Shi Z
Open medicine (Warsaw, Poland) 2019;14:516-522

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Microglial activation in an amyotrophic lateral sclerosis-like model caused by Ranbp2 loss and nucleocytoplasmic transport impairment in retinal ganglion neurons.

Cho KI, Yoon D, Yu M, Peachey NS, Ferreira PA
Cellular and molecular life sciences : CMLS 2019 Sep;76(17):3407-3432

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Chronic restraint stress disturbs meiotic resumption through APC/C-mediated cyclin B1 excessive degradation in mouse oocytes.

Sun J, Guo Y, Zhang Q, Bu S, Li B, Wang Q, Lai D
Cell cycle (Georgetown, Tex.) 2018;17(13):1591-1601

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APC/C(CDC20) and APC/C play pivotal roles in the process of embryonic development in Artemia sinica.

Zhang M, Yao F, Luan H, Zhao W, Jing T, Zhang S, Hou L, Zou X
Scientific reports 2016 Dec 19;6:39047

Immunocytochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunofluorescent analysis of HepG2 cells, using PTTG1 antibody 18040-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).

Sample type

cell line