18040-1-AP

antibody from Proteintech Group

Targeting: PTTG1 EAP1, HPTTG, PTTG, securin, TUTR1

Provider product page for 18040-1-AP

ELISA

Immunocytochemistry

Antibody data

Antibody Data
Antigen structure
References [16]
Comments [0]
Validations
Immunocytochemistry [1]

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Product number: 18040-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#18040-1-AP, RRID:AB_2173410
Product name: Securin / PTTG1 antibody
Antibody type: Polyclonal
Description: KD/KO validated Securin / PTTG1 antibody (Cat. #18040-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

PTTG1 protein structure - 18040-1-AP shown in red.

Submitted references The Hypoxia-Associated High-Risk Cell Subpopulation Distinctly Enhances the Progression of Glioma.

Wan Q, Wu X, Zhou J, Wu W, Cao Y, Sun C, Li Z, Gong Z, Tang H, Li Q, Chu J, Wang Q, Cui K, Lu X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 May;12(17):e2416231

Molecular feature-based classification of retroperitoneal liposarcoma: a prospective cohort study.

Xiao M, Li X, Bu F, Ma S, Yang X, Chen J, Zhao Y, Cananzi F, Luo C, Min L
eLife 2025 May 23;14

Integrative network and computational toxicology reveal the molecular mechanisms in PFOA-induced spermatogenic disorder.

Luo Y, Xue E, Zhao Y, Lu H, Xiang D, Zhou Y, Zhan J, Li Z, Sun F
Journal of environmental management 2025 Jun;386:125754

Knockdown of KLF6 ameliorates myocardial infarction by regulating autophagy via transcriptional regulation of PTTG1.

Chen Y, Zhao Q, Wu T, Sun F, Fu W
American journal of physiology. Cell physiology 2025 Jan 1;328(1):C115-C127

UBE2C promotes pancreatic tumorigenesis by KRAS stabilization via APC/C(CDH1)-mediated WDR76 degradation.

Wang L, Chen X, Qu R, Shao S, Gong L, Li T, Jiang S, Lu Y, Ma Y, Sun Y, Cui D, Xiong X, Zhao Y
Cancer letters 2025 Aug 30;633:218013

Identification and validation of tryptophan-related gene signatures to predict prognosis and immunotherapy response in lung adenocarcinoma reveals a critical role for PTTG1.

Wang Z, Zhang J, Zuo C, Chen H, Wang L, Xie Y, Ma H, Min S, Wang X, Lian C
Frontiers in immunology 2024;15:1386427

Multi-omics analysis identifies PTTG1 as a prognostic biomarker associated with immunotherapy and chemotherapy resistance.

Wei H, Ma Y, Chen S, Zou C, Wang L
BMC cancer 2024 Oct 25;24(1):1315

Multi-omic analysis revealed the immunological patterns and diagnostic value of exhausted T cell-derived PTTG1 in patients with psoriasis.

Zhou X, Ning J, Cai R, Liu J, Yang H, Liu Q, Lv J, Bai Y
Biochemical and biophysical research communications 2024 Nov 19;734:150740

Securin acetylation prevents precocious separase activation and premature sister chromatid separation.

Wang T, Zou Y, Meng H, Zheng P, Teng J, Huang N, Chen J
Current biology : CB 2024 Mar 25;34(6):1295-1308.e5

Homozygous variants in CDC23 cause female infertility characterized by oocyte maturation defects.

Fan H, Zhou Z, Zheng W, Guan Y, Meng Q, Wang W, Dong J, Wan L, Zhu J, Zeng Y, Liu R, Gu H, Lin G, Chen B, Sang Q, Wang L
Human genetics 2023 Nov;142(11):1621-1631

Phosphorylated PTTG1 switches its subcellular distribution and promotes β-catenin stabilization and subsequent transcription activity.

Zhang X, Wu N, Huang H, Li S, Liu S, Zhang R, Huang Y, Lyu H, Xiao S, Ali DW, Michalak M, Chen XZ, Zhou C, Tang J
Oncogene 2023 Aug;42(32):2439-2455

Melatonin promotes in vitro maturation of vitrified-warmed mouse GV oocytes potentially by modulating MAD2 protein expression of SAC component through MTRs.

Yang J, Guo S, Pan B, Qazi IH, Qin J, Zang S, Han H, Meng Q, Zhou G
Cryobiology 2021 Oct;102:82-91

The Pseudogene PTTG3P Promotes Cell Migration and Invasion in Esophageal Squamous Cell Carcinoma.

Zhang Z, Shi Z
Open medicine (Warsaw, Poland) 2019;14:516-522

Microglial activation in an amyotrophic lateral sclerosis-like model caused by Ranbp2 loss and nucleocytoplasmic transport impairment in retinal ganglion neurons.

Cho KI, Yoon D, Yu M, Peachey NS, Ferreira PA
Cellular and molecular life sciences : CMLS 2019 Sep;76(17):3407-3432

Chronic restraint stress disturbs meiotic resumption through APC/C-mediated cyclin B1 excessive degradation in mouse oocytes.

Sun J, Guo Y, Zhang Q, Bu S, Li B, Wang Q, Lai D
Cell cycle (Georgetown, Tex.) 2018;17(13):1591-1601

APC/C(CDC20) and APC/C play pivotal roles in the process of embryonic development in Artemia sinica.

Zhang M, Yao F, Luan H, Zhao W, Jing T, Zhang S, Hou L, Zou X
Scientific reports 2016 Dec 19;6:39047

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunofluorescent analysis of HepG2 cells, using PTTG1 antibody 18040-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
Sample type: cell line