Tissue expression
Cell line expression

PTTG1

gene product
EAP1, HPTTG, PTTG, securin, TUTR1 
The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013]
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474 antibodies from 38 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
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1 antibody
Atlas Antibodies
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RabMAbs
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ProSci
1 antibody
Bioss
2 antibodies
Abbkine Scientific Co.Ltd.
1 antibody
Cell Signaling Technology, Inc
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1 antibody
MyBioSource
5 antibodies
Arigo
3 antibodies
NSJ Bioreagents
2 antibodies
Abbexa
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1 antibody
Spring Bioscience
4 antibodies
Leading Biology
3 antibodies
Creative Biolabs
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Creative Diagnostics
3 antibodies
United States Biological
63 antibodies
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MilliporeSigma / Merck KGaA
2 antibodies
GenWay
1 antibody