TBX18

This genes codes for a member of an evolutionarily conserved family of transcription factors that plays a crucial role in embryonic development. The family is characterized by the presence of the DNA-binding T-box domain and is divided into five sub-families based on sequence conservation in this domain. The encoded protein belongs to the vertebrate specific Tbx1 sub-family. The protein acts as a transcriptional repressor by antagonizing transcriptional activators in the T-box family. The protein forms homo- or heterodimers with other transcription factors of the T-box family or other transcription factors. [provided by RefSeq, Nov 2012]

Description

T-box transcription factor 18

Protein family

Disease related genes, Mapped to neXtProt, Mapped to UniProt SWISS-PROT, Predicted intracellular proteins, Protein evidence (Peptideatlas), Transcription factors

Chromosome

6:q14.3 (84687351 - 84764598)

Ensembl ID

ENSG00000112837  (ver. 99.38)

Orthologs

Mouse Tbx18: ENSMUSG00000032419

UniProt

O95935

neXtProt

NX_O95935

Human splice variants
Mouse splice variants