GTX70262

antibody from GeneTex

Targeting: XRCC1 RCC

Western blot (Recommended by provider)

Immunoprecipitation (Recommended by provider)

Antibody Data

Product number

GTX70262

Provider

GeneTex

Proper citation

GeneTex Cat#GTX70262, RRID:AB_373302

Product name

XRCC1 antibody

Antibody type

Polyclonal

Antigen

Recombinant human XRCC1

Host

Rabbit

Isotype

IgG

Vial size

50µl

Concentration

1mg/ml

Storage

Keep as concentrated solution. Store at 4°C short term. For extended storage aliquot and store at -20°C or below. Avoid freeze-thaw cycles.

References

Submitted references

The interaction between polynucleotide kinase phosphatase and the DNA repair protein XRCC1 is critical for repair of DNA alkylation damage and stable association at DNA damage sites.

Della-Maria J, Hegde ML, McNeill DR, Matsumoto Y, Tsai MS, Ellenberger T, Wilson DM 3rd, Mitra S, Tomkinson AE
The Journal of biological chemistry 2012 Nov 9;287(46):39233-44

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Human DNA polymerase beta polymorphism, Arg137Gln, impairs its polymerase activity and interaction with PCNA and the cellular base excision repair capacity.

Guo Z, Zheng L, Dai H, Zhou M, Xu H, Shen B
Nucleic acids research 2009 Jun;37(10):3431-41

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XRCC1 stimulates human polynucleotide kinase activity at damaged DNA termini and accelerates DNA single-strand break repair.

Whitehouse CJ, Taylor RM, Thistlethwaite A, Zhang H, Karimi-Busheri F, Lasko DD, Weinfeld M, Caldecott KW
Cell 2001 Jan 12;104(1):107-17