21468-1-AP

antibody from Proteintech Group

Targeting: XRCC1 RCC

Provider product page for 21468-1-AP

Western blot

ELISA

Immunocytochemistry

Antibody data

Antibody Data
Antigen structure
References [16]
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Product number: 21468-1-AP - Provider product page
Provider: Proteintech Group
Product name: XRCC1 antibody
Antibody type: Polyclonal
Description: KD/KO validated XRCC1 antibody (Cat. #21468-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, WB,ELISA.
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

XRCC1 protein structure - 21468-1-AP shown in red.

Submitted references USP5-mediated CD73 deubiquitination drives osimertinib resistance via PI3K/AKT and glycolysis activation in LUAD.

Chen R, Han XH, Zhang Z, Han XJ, Xie J
iScience 2026 Mar 20;29(3):114916

Overexpression of the ERG oncogene in prostate cancer identifies candidates for PARP inhibitor-based radiosensitization.

Köcher S, Elsesy ME, Moustafa A, Mohammadi W, Perugachi Heinsohn A, Nagaraj Y, Oh-Hohenhorst SJ, Hahn J, Siebels B, Mair T, Burdak-Rothkamm S, Tennstedt P, Simon R, Lange T, Tilki D, Frenzel T, Maurer T, Petersen C, Schlüter H, Bokemeyer C, von Amsberg G, Rothkamm K, Mansour WY
The Journal of clinical investigation 2026 Mar 16;136(6)

RBM39 Promotes Base Excision Repair to Facilitate the Progression of HCC by Stabilising OGG1 mRNA.

An H, Xia A, Liu S, Luo D, Geng L, Li B, Sun B, Xu Z
Cell proliferation 2025 Oct;58(10):e70059

KLC3 activates PI3K/AKT signaling and promotes ovarian cancer cell proliferation and migration through COL3A1.

Yang J, He R, Zhang X, Wang X, Liu M, Liu X, Li Y
Oncology reports 2025 Jun;53(6)

Extrachromosomal DNA replication and maintenance couple with DNA damage pathway in tumors.

Kang X, Li X, Zhou J, Zhang Y, Qiu L, Tian C, Deng Z, Liang X, Zhang Z, Du S, Hu S, Wang N, Yue Z, Xu Y, Gao Y, Dai J, Wang Z, Yu C, Chen J, Wu Y, Chen L, Yao Y, Yao S, Yang X, Yan L, Wen Q, Depies OM, Chan K, Liang X, Li G, Zi Z, Liu X, Gan H
Cell 2025 Jun 26;188(13):3405-3421.e27

The dysregulation of PARP9 expression is linked to apoptosis and DNA damage in gastric cancer cells.

Li Y, Wang X, Liu X, Li X, Zhang J, Li Y
PloS one 2024;19(12):e0316476

DNA polymerase beta connects tumorigenicity with the circadian clock in liver cancer through the epigenetic demethylation of Per1.

Chen S, Zhang W, Li X, Cao Z, Liu C
Cell death & disease 2024 Jan 20;15(1):78

D-type cyclins regulate DNA mismatch repair in the G1 and S phases of the cell cycle, maintaining genome stability.

Rona G, Miwatani-Minter B, Zhang Q, Goldberg HV, Kerzhnerman MA, Howard JB, Simoneschi D, Lane E, Hobbs JW, Sassani E, Wang AA, Keegan S, Laverty DJ, Piett CG, Pongor LS, Xu ML, Andrade J, Thomas A, Sicinski P, Askenazi M, Ueberheide B, Fenyö D, Nagel ZD, Pagano M
bioRxiv : the preprint server for biology 2024 Jan 13;

CDK-independent role of D-type cyclins in regulating DNA mismatch repair.

Retrotransposons hijack alt-EJ for DNA replication and eccDNA biogenesis.

Yang F, Su W, Chung OW, Tracy L, Wang L, Ramsden DA, Zhang ZZZ
Nature 2023 Aug;620(7972):218-225

KDM6B promotes PARthanatos via suppression of O6-methylguanine DNA methyltransferase repair and sustained checkpoint response.

Yang M, Wang C, Zhou M, Bao L, Wang Y, Kumar A, Xing C, Luo W, Wang Y
Nucleic acids research 2022 Jun 24;50(11):6313-6331

XRCC1 Is a Promising Predictive Biomarker and Facilitates Chemo-Resistance in Gallbladder Cancer.

Wu Z, Miao X, Zhang Y, Li D, Zou Q, Yuan Y, Liu R, Yang Z
Frontiers in molecular biosciences 2020;7:70

Effects of DNA Damage and Oxidative Stress in Human Bronchial Epithelial Cells Exposed to PM(2.5) from Beijing, China, in Winter.

Niu BY, Li WK, Li JS, Hong QH, Khodahemmati S, Gao JF, Zhou ZX
International journal of environmental research and public health 2020 Jul 6;17(13)

Berberine attenuates XRCC1-mediated base excision repair and sensitizes breast cancer cells to the chemotherapeutic drugs.

Gao X, Wang J, Li M, Wang J, Lv J, Zhang L, Sun C, Ji J, Yang W, Zhao Z, Mao W
Journal of cellular and molecular medicine 2019 Oct;23(10):6797-6804

Exosomes Serve as Nanoparticles to Deliver Anti-miR-214 to Reverse Chemoresistance to Cisplatin in Gastric Cancer.

Wang X, Zhang H, Bai M, Ning T, Ge S, Deng T, Liu R, Zhang L, Ying G, Ba Y
Molecular therapy : the journal of the American Society of Gene Therapy 2018 Mar 7;26(3):774-783

Polychlorinated biphenyl quinone induces oxidative DNA damage and repair responses: The activations of NHEJ, BER and NER via ATM-p53 signaling axis.

Dong H, Shi Q, Song X, Fu J, Hu L, Xu D, Su C, Xia X, Song E, Song Y
Toxicology and applied pharmacology 2015 Jul 1;286(1):10-6

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