BS6713

antibody from Bioworld Technology, Inc
Targeting: PSMC5 p45, p45/SUG, S8, SUG-1, SUG1, TBP10, TRIP1
Provider product page for BS6713
Western blot
Immunocytochemistry
Immunohistochemistry

Antibody data

Product number
BS6713 - Provider product page
Provider
Bioworld Technology, Inc
Product name
PSMC5 polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human PSMC5.
Description
The 26S proteasome is a highly ordered proteinase complex consisting of a 20S core and a 19S regulator. While the core is responsible for the proteolytic activity of the proteasome, the regulator contains several ATPase subunits which function in the ATP-dependent degradation of ubiquitinated proteins and confer substrate specificity to the 26S complex. SUG1, also known as PSMC5 (Proteasome 26S subunit ATPase 5), p45 or S8, is an ATPase subunit that is an integral part of the 26S proteasome complex. Localized to the cytoplasm and nucleus, SUG1 is part of the 19S regulator and functions in the ubiquitin/proteasome-mediated degradation of proteins (specifically receptors) found in the endoplasmic reticulum (ER). Recent studies suggest that assembly of the 26S proteasome is dependent upon phosphorylation of SUG1 by a protein kinase. In vitro, SUG1 also interacts with RXR (retinoid X receptor) and TR (thyroid hormone receptor), suggesting a possible role in transcriptional regulation
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
PSMC5 protein structure - BS6713 shown in red.