PSMC5

gene product
p45, p45/SUG, S8, SUG-1, SUG1, TBP10, TRIP1
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. In addition to participation in proteasome functions, this subunit may participate in transcriptional regulation since it has been shown to interact with the thyroid hormone receptor and retinoid X receptor-alpha. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
More gene data

Featured antibodies

Antibodies

 

Filters

Application

Antibodypedia Validation Initiative

Validation method

Reference

Provider

Host

Reactivity

Antibody type

Conjugate

  or   Clear
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider
Validated within AVI
Eligible for validation within AVI
282 antibodies from 32 providers.

Antibody properties

General

Applications

or Cancel
AntibodyRefsTypeWBELICCIPIHCFC
Novus Biologicals
19 antibodies
Atlas Antibodies
2 antibodies
antibodies-online
107 antibodies
Enzo Life Sciences
10 antibodies
GeneTex
6 antibodies
Invitrogen Antibodies
6 antibodies
Biorbyt
9 antibodies
OriGene
2 antibodies
Abnova Corporation
4 antibodies
Aviva Systems Biology
1 antibody
LifeSpan BioSciences, Inc.
23 antibodies
Bioworld Technology, Inc
1 antibody
Affinity Biosciences
3 antibodies
Bethyl Laboratories
3 antibodies
Boster Biological Technology
2 antibodies
NovoPro Bioscience Inc.
1 antibody
St John's Laboratory
2 antibodies
Creative Biolabs
15 antibodies
Creative Diagnostics
6 antibodies
ProSci
2 antibodies
Acris Antibodies GmbH
1 antibody
RabMAbs
2 antibodies
United States Biological
26 antibodies
MyBioSource
5 antibodies
Abgent
2 antibodies
Cell Signaling Technology, Inc
1 antibody
Sigma-Aldrich
3 antibodies
Abbexa
3 antibodies
Arigo
1 antibody
GenWay
1 antibody
RayBiotech, Inc.
1 antibody