14768-1-AP

antibody from Proteintech Group

Targeting: FEN1 FEN-1, MF1, RAD2

Provider product page for 14768-1-AP

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Immunocytochemistry

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Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [21]
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Validations
Western blot [1]

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Product number: 14768-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#14768-1-AP, RRID:AB_2102780
Product name: FEN1 antibody
Antibody type: Polyclonal
Description: FEN1 antibody (Cat. #14768-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

FEN1 protein structure - 14768-1-AP shown in red.

Submitted references Demethyleneberberine alleviates cellular senescence of human fibroblasts by directly activating FEN1.

Jiang M, Yan X, Zhang P, Guo P, Hu R, Zhai W, Xu Q, Hu S, Churov AV, Wu Z
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2026 May;198:119252

Flap endonuclease 1 drives tumorigenesis across cancers and is a master regulator of proliferation and genomic instability in liver cancer.

Li F, Ji X, Zhang Y, Liu A, Li R, Peng X, Wang Y, Mei J, Yang Y, Wang Y, Wu L, Wang B, Zhang Y
International journal of biological macromolecules 2026 Mar;349:150875

N-α-Acetyltransferase 40 promotes oral squamous cell carcinoma progression by enhancing FEN1 transcription and suppressing CD8(+) T cell antitumor immunity.

Jiao K, Jin L, Zheng Y, Zhang Y, Cui Z
Cellular signalling 2026 Mar;139:112335

CircRNA0052011 modulates DNA damage and repair via FEN1 ubiquitination to mitigate polystyrene nanoplastics-induced genotoxicity in the lung.

Lan M, Zhong C, Xu X, He M, Fan L, Lu W, Qiu L, Fang J, Wang J, Wang S, Deng Z, Chen Y, Qiu L, Chen X, Jiang Y, Zhou Y
Environment international 2026 Apr;210:110211

CypD Dependent mPTP Opening Is Crucial for Oxidized Mitochondrial DNA Release in Ferroptosis.

Zhou H, Fu W, Liu S, Zhang Z, Luo H, Zhong Q
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr;13(20):e02239

Pathways and products of base excision DNA repair in Xenopus laevis eggs: contrast with human cell pathways.

Xue Z, Sutton PJ, Haley JD, Brownlee CW, Demple B
Nucleic acids research 2025 Nov 26;53(22)

Extrachromosomal DNA replication and maintenance couple with DNA damage pathway in tumors.

Kang X, Li X, Zhou J, Zhang Y, Qiu L, Tian C, Deng Z, Liang X, Zhang Z, Du S, Hu S, Wang N, Yue Z, Xu Y, Gao Y, Dai J, Wang Z, Yu C, Chen J, Wu Y, Chen L, Yao Y, Yao S, Yang X, Yan L, Wen Q, Depies OM, Chan K, Liang X, Li G, Zi Z, Liu X, Gan H
Cell 2025 Jun 26;188(13):3405-3421.e27

Proteomics analysis reveals FEN1 as a promising therapeutic target against small cell neuroendocrine carcinoma of the cervix.

Liu J, Zhong M, Yang K, Wang J, Ma H, Wang W, Sun L, Liu L, Xu J, Cui X, Hao J, Li L
Scientific reports 2025 Jul 30;15(1):27827

Inhibition of the FEN1-PBX1 axis elicits cellular senescence in breast cancer via the increased intracellular reactive oxygen species levels.

Wu M, Wu B, Huang X, Wang Z, Zhu M, Zhu Y, Yu L, Liu J
Journal of translational medicine 2025 Feb 28;23(1):248

Harmine inhibits pulmonary fibrosis through regulating DNA damage repair-related genes and activation of TP53-Gadd45α pathway.

Gong Y, Wang J, Pan M, Zhao Y, Zhang H, Zhang F, Liu J, Yang J, Hu J
International immunopharmacology 2024 Sep 10;138:112542

DNA polymerase beta connects tumorigenicity with the circadian clock in liver cancer through the epigenetic demethylation of Per1.

Chen S, Zhang W, Li X, Cao Z, Liu C
Cell death & disease 2024 Jan 20;15(1):78

Primate-Specific DAZ Regulates Translation of Cell Proliferation-Related mRNAs and is Essential for Maintenance of Spermatogonia.

Ou N, Wang Y, Xu S, Luo J, Zhang C, Zhang Y, Shi X, Xiong M, Zhao L, Ji Z, Zhang Y, Zhao J, Bai H, Tian R, Li P, Zhi E, Huang Y, Chen W, Wang R, Jin Y, Wang D, Li Z, Chen H, Yao C
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Aug;11(29):e2400692

CJ(2): A Novel Potent Platinum(IV) Prodrug Enhances Chemo-Immunotherapy by Facilitating PD-L1 Degradation in the Cytoplasm and Cytomembrane.

Fan R, Deng A, Qi B, Zhang S, Sang R, Luo L, Gou J, Liu Y, Lin R, Zhao M, Liu Y, Yang L, Cheng M, Wei G
Journal of medicinal chemistry 2023 Jan 12;66(1):875-889

Causal genetic regulation of DNA replication on immune microenvironment in colorectal tumorigenesis: Evidenced by an integrated approach of trans-omics and GWAS.

Wang S, Chen S, Li H, Ben S, Zhao T, Zheng R, Wang M, Gu D, Liu L
Journal of biomedical research 2023 Dec 18;38(1):37-50

HIV-1 exploits the Fanconi anemia pathway for viral DNA integration.

Fu S, Phan AT, Mao D, Wang X, Gao G, Goff SP, Zhu Y
Cell reports 2022 May 24;39(8):110840

Cis- and trans-resveratrol have opposite effects on histone serine-ADP-ribosylation and tyrosine induced neurodegeneration.

Jhanji M, Rao CN, Massey JC, Hope MC 3rd, Zhou X, Keene CD, Ma T, Wyatt MD, Stewart JA, Sajish M
Nature communications 2022 Jun 10;13(1):3244

In Situ Peroxidase Labeling Followed by Mass-Spectrometry Reveals TIA1 Interactome.

Gourdomichali O, Zonke K, Kattan FG, Makridakis M, Kontostathi G, Vlahou A, Doxakis E
Biology 2022 Feb 11;11(2)

Upregulation of FEN1 Is Associated with the Tumor Progression and Prognosis of Hepatocellular Carcinoma.

Zhang Y, Liu X, Liu L, Chen J, Hu Q, Shen S, Zhou Y, Chen S, Xue C, Cui G, Yu Z
Disease markers 2020;2020:2514090

Succinylation at a key residue of FEN1 is involved in the DNA damage response to maintain genome stability.

Shi R, Wang Y, Gao Y, Xu X, Mao S, Xiao Y, Song S, Wang L, Tian B, Zhao Y, Hua Y, Xu H
American journal of physiology. Cell physiology 2020 Oct 1;319(4):C657-C666

SUMO-1 modification of FEN1 facilitates its interaction with Rad9-Rad1-Hus1 to counteract DNA replication stress.

Xu X, Shi R, Zheng L, Guo Z, Wang L, Zhou M, Zhao Y, Tian B, Truong K, Chen Y, Shen B, Hua Y, Xu H
Journal of molecular cell biology 2018 Oct 1;10(5):460-474

Synergistic antitumor effect of combined paclitaxel with FEN1 inhibitor in cervical cancer cells.

He L, Yang H, Zhou S, Zhu H, Mao H, Ma Z, Wu T, Kumar AK, Kathera C, Janardhan A, Pan F, Hu Z, Yang Y, Luo L, Guo Z
DNA repair 2018 Mar;63:1-9

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The FEN1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human FEN1. This antibody recognizes human, mouse, rat antigen. The FEN1 antibody has been validated for the following applications: ELISA, WB analysis.
Appendix: 14768-1-AP.pdf

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