Tissue expression
Cell line expression

FEN1

gene product
FEN-1, MF1, RAD2 
The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore, secondary structure can deter the protective function of this protein, leading to site-specific trinucleotide expansions. [provided by RefSeq, Jul 2008]
More gene data

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577 antibodies from 39 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
GeneTex
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NSJ Bioreagents
1 antibody
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3 antibodies
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1 antibody
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NovoPro Bioscience Inc.
1 antibody
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1 antibody
Invitrogen Antibodies
17 antibodies
Biorbyt
17 antibodies
Aviva Systems Biology
5 antibodies
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Affinity Biosciences
3 antibodies
St John's Laboratory
5 antibodies
HUABIO Research
1 antibody
Bioworld Technology, Inc
2 antibodies
Bethyl Laboratories
3 antibodies
Acris Antibodies GmbH
6 antibodies
Arigo
2 antibodies
Abgent
3 antibodies
Atlas Antibodies
1 antibody
Abbkine Scientific Co.Ltd.
1 antibody
Creative Diagnostics
7 antibodies
Abbexa
10 antibodies
Abnova Corporation
6 antibodies
RabMAbs
5 antibodies
MyBioSource
11 antibodies
Creative Biolabs
26 antibodies
ProSci
2 antibodies
United States Biological
39 antibodies
Cell Signaling Technology, Inc
2 antibodies
MilliporeSigma / Merck KGaA
5 antibodies
GenWay
5 antibodies
RayBiotech, Inc.
1 antibody
Absolute Antibody
2 antibodies
CPTAC
1 antibody