Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations [0]
Submit
Validation data
Reference
Comment
Report error
- Product number
- CABT-RM129 - Provider product page
- Provider
- Creative Diagnostics
- Product name
- Mouse Anti-PRDM1 monoclonal antibody, clone SPT206H
- Antibody type
- Monoclonal
- Description
- PR domain zinc finger protein 1 is encoded by the PRDM1 gene in human. BLIMP-1 is a transcriptional repressor that is required for terminal B-cell differentiation into plasma cells. During B-cell differentiation, it actively represses the transcription of the c-Myc gene through binding its promoter. It is considered as a master regulator in terminal B-cell differentiation and has also been identified as a tumor suppressor target for mutational inactivation in diffuse large B-cell lymphomas. BLIMP-1 expression has been demonstrated in a subset of diffuse large B-cell lymphoma (DLBCL) with aggressive behavior. It also plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs. BLIMP-1 is reported to be a target for microRNA-mediated down-regulation by miR-9 and let-7a in Hodgkin/ Reed-Sternberg cells of Hodgkin lymphoma. BLIMP-1 contains four C2H2 type zinc finger domains and a SET domain (aa 84-201). Its sumolyation at Lysine 816 by E3 SUMO-protein ligase PIAS1 augments its transcriptional repressor activity and is also essential for plasma cell differentiation. Three isoforms of BLIMP-1 have been described that are produced by alternative splicing.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
No comments: Submit comment
No validations: Submit validation data