CABT-RM129

antibody from Creative Diagnostics

Targeting: PRDM1 BLIMP1, PRDI-BF1

Western blot (Recommended by provider)

Immunoprecipitation (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

CABT-RM129

Provider

Creative Diagnostics

Product name

Mouse Anti-PRDM1 monoclonal antibody, clone SPT206H

Antibody type

Monoclonal

Description

PR domain zinc finger protein 1 is encoded by the PRDM1 gene in human. BLIMP-1 is a transcriptional repressor that is required for terminal B-cell differentiation into plasma cells. During B-cell differentiation, it actively represses the transcription of the c-Myc gene through binding its promoter. It is considered as a master regulator in terminal B-cell differentiation and has also been identified as a tumor suppressor target for mutational inactivation in diffuse large B-cell lymphomas. BLIMP-1 expression has been demonstrated in a subset of diffuse large B-cell lymphoma (DLBCL) with aggressive behavior. It also plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs. BLIMP-1 is reported to be a target for microRNA-mediated down-regulation by miR-9 and let-7a in Hodgkin/ Reed-Sternberg cells of Hodgkin lymphoma. BLIMP-1 contains four C2H2 type zinc finger domains and a SET domain (aa 84-201). Its sumolyation at Lysine 816 by E3 SUMO-protein ligase PIAS1 augments its transcriptional repressor activity and is also essential for plasma cell differentiation. Three isoforms of BLIMP-1 have been described that are produced by alternative splicing.

Reactivity

Human

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG