Tissue expression
Cell line expression
Protein structure
TIRAP
TIR domain containing adaptor proteinMal, wyatt
The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]
Top validated antibodies |
|||||
Invitrogen Antibodies | PA5-88657 | 2 references | Polyclonal |
WB
ICC
IHC
OA |
|
GeneTex | GTX31676 | Polyclonal |
WB
EL
ICC
IHC |
||
LSBio | LS-C747701 | Polyclonal |
WB
ICC
IHC
|
||
Novus Biologicals | NB300-990 | 2 references | Polyclonal |
WB
EL
PLA
|
|
Abnova Corporation | PAB13113 | 3 references | Polyclonal |
WB
IHC |
All Antibodies
Filters
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider