GTF2H3

This gene encodes a member of the TFB4 family. The encoded protein is a subunit of the core-TFIIH basal transcription factor and localizes to the nucleus. The encoded protein is involved in RNA transcription by RNA polymerase II and nucleotide excision repair and associates with the Cdk-activating kinase complex. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 14. [provided by RefSeq, Dec 2012]

Description

General transcription factor IIH subunit 3

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

12 (123633739 - 123662604)

Ensembl ID

ENSG00000111358  (ver. 103.38)

Orthologs

Mouse Gtf2h3: ENSMUSG00000029387

UniProt

Q13889

neXtProt

NX_Q13889

Human splice variants
Mouse splice variants

Protein structure