GPR153

This gene encodes an integral membrane protein that belongs to the Class A rhodopsin superfamily of G protein coupled receptors. The encoded protein is expressed primarily in the central nervous system. A knockdown of the orthologous gene in rat is associated with a significant reduction in food intake and impaired decision making ability. Mutations in this gene are associated with schizophrenia, autism, and other neuropsychiatric disorders. The expression of this gene is activated by the glioma-associated oncogene homolog 1 transcription factor which, in turn, is activated by sonic hedgehog in normal and tumorigenic cells. [provided by RefSeq, Feb 2017]

Description

G protein-coupled receptor 153

Tissue specificity

Low tissue specificity

Predicted location

Membrane

Protein family

G-protein coupled receptors
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins

Chromosome

1 (6247353 - 6261098)

Ensembl ID

ENSG00000158292  (ver. 103.38)

Orthologs

Mouse Gpr153: ENSMUSG00000042804

UniProt

Q6NV75

neXtProt

NX_Q6NV75

Human splice variants
Mouse splice variants

Protein structure