BS4643

antibody from Bioworld Technology, Inc

Targeting: DAB1

Western blot (Data presented on provider website)

Antibody Data

Product number

BS4643

Provider

Bioworld Technology, Inc

Product name

Dab1 (phospho Y232) polyclonal antibody

Antibody type

Polyclonal

Antigen

Synthetic phosphopeptide derived from human Dab1 around the phosphorylation site of Tyrosine 232.

Description

Dab1, a homolog of the Drosophila Disabled protein, is an adaptor protein involved in neural development. This cytoplasmic protein is tyrosine-phosphorylated during rapid expansion of the developing nervous system, and it is thought to interact with other proteins via a domain similar to the PTB domains of the Shc family. Dab1 has been shown to interact with the SH2 domains of Src, Fyn and Abl. Mutations in Dab1 result in widespread abnormalities in the brain, similar to those seen in Reelin mutants. Reelin is a secreted protein thought to play a role in directing migrating neurons. Evidence suggests that Dab1 functions downstream of Reelin in a signaling pathway involved in positioning cells in the developing brain

Reactivity

Human, Mouse, Rat

Host

Rabbit

Isotype

IgG

Vial size

100ul

Concentration

1 mg/ml

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.