DAB1

The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. This gene is similar to disabled-1, and the protein encoded by this gene is thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. [provided by RefSeq, Jul 2008]

Description

Dab, reelin signal transducer, homolog 1 (Drosophila)

Protein family

Mapped to UniProt SWISS-PROT, Predicted intracellular proteins, Protein evidence (Ezkurdia et al 2014), Protein evidence (Kim et al 2014)

Chromosome

1 (56994778 - 58546734)

Ensembl ID

ENSG00000173406  (ver. 84.38)

Orthologs

Mouse Dab1: ENSMUSG00000028519

UniProt

O75553

neXtProt

NX_O75553

Human splice variants
Mouse splice variants