DAB1

The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. This gene is similar to disabled-1, and the protein encoded by this gene is thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain. [provided by RefSeq, Jan 2017]

Description

DAB adaptor protein 1

Protein family

Disease related genes, Mapped to neXtProt, Mapped to UniProt SWISS-PROT, Predicted intracellular proteins, Protein evidence (Peptideatlas)

Chromosome

1 (56994778 - 58546734)

Ensembl ID

ENSG00000173406  (ver. 99.38)

Orthologs

Mouse Dab1: ENSMUSG00000028519

UniProt

O75553

neXtProt

NX_O75553

Human splice variants
Mouse splice variants