PTGFR

The protein encoded by this gene is member of the G-protein coupled receptor family. This protein is a receptor for prostaglandin F2-alpha (PGF2-alpha), which is known to be a potent luteolytic agent, and may also be involved in modulating intraocular pressure and smooth muscle contraction in uterus. Knockout studies in mice suggest that the interaction of PGF2-alpha with this receptor may initiate parturition in ovarian luteal cells and thus induce luteolysis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Description

Prostaglandin F receptor

Tissue specificity

Tissue enhanced (tongue)

Predicted location

Membrane

Protein family

FDA approved drug targets
G-protein coupled receptors
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins

Chromosome

1 (78303884 - 78540701)

Ensembl ID

ENSG00000122420  (ver. 103.38)

Orthologs

Mouse Ptgfr: ENSMUSG00000028036

UniProt

P43088

neXtProt

NX_P43088

Human splice variants
Mouse splice variants

Protein structure