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- Product number
- 12994-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12994-1-AP, RRID:AB_10644276
- Product name
- SIRT7 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated SIRT7 antibody (Cat. #12994-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Sirt7/HIC1 complex participates in hyperglycaemia-mediated EndMT via modulation of SDC1 expression in diabetic kidney disease and metabolic memory.
KSHV vIL-6 promotes SIRT3-induced deacetylation of SERBP1 to inhibit ferroptosis and enhance cellular transformation by inducing lipoyltransferase 2 mRNA degradation.
Sirt6 regulates the proliferation of neural precursor cells and cortical neurogenesis in mice.
N(6)-methyladenosine of Spi2a attenuates inflammation and sepsis-associated myocardial dysfunction in mice.
USP17L2-SIRT7 axis regulates DNA damage repair and chemoresistance in breast cancer cells.
Aberrant methylmalonylation underlies methylmalonic acidemia and is attenuated by an engineered sirtuin.
Data of RNA-seq transcriptomes of liver, bone, heart, kidney and blood in klotho mice at a pre-symptomatic state and the effect of a traditional Japanese multi-herbal medicine, juzentaihoto.
A new FGF1 variant protects against adriamycin-induced cardiotoxicity via modulating p53 activity.
The prognostic implications of SIRTs expression in breast cancer: a systematic review and meta-analysis.
Influence of psychostimulants and opioids on epigenetic modification of class III histone deacetylase (HDAC)-sirtuins in glial cells.
Lycorine hydrochloride suppresses stress-induced premature cellular senescence by stabilizing the genome of human cells.
Intron retention as a new pre-symptomatic marker of aging and its recovery to the normal state by a traditional Japanese multi-herbal medicine.
The effects of A549 and H1299 cell-derived exosomes on the proliferation and apoptosis of BEAS-2B cells.
Sirtuin 7 promotes non‑small cell lung cancer progression by facilitating G1/S phase and epithelial‑mesenchymal transition and activating AKT and ERK1/2 signaling.
Elevation of JAML Promotes Diabetic Kidney Disease by Modulating Podocyte Lipid Metabolism.
SIRT7 Regulates Lipopolysaccharide-Induced Inflammatory Injury by Suppressing the NF-κB Signaling Pathway.
Comprehensive Analysis of Expression and Prognostic Value of Sirtuins in Ovarian Cancer.
SIRT7 depletion inhibits cell proliferation, migration, and increases drug sensitivity by activating p38MAPK in breast cancer cells.
Sirt6 deficiency exacerbates podocyte injury and proteinuria through targeting Notch signaling.
MicroRNA-148a deficiency promotes hepatic lipid metabolism and hepatocarcinogenesis in mice.
An asymmetrically dimethylarginated nuclear 90 kDa protein (p90aDMA) induced by interleukin (IL)-2, IL-4 or IL-6 in the tumor microenvironment is selectively degraded by autophagy.
High expression of Sirt7 served as a predictor of adverse outcome in breast cancer.
Lu L, Zhu M, Wu Q, Sun Z, Chen X, Miao C
Journal of cellular and molecular medicine 2024 May;28(9):e18336
Journal of cellular and molecular medicine 2024 May;28(9):e18336
KSHV vIL-6 promotes SIRT3-induced deacetylation of SERBP1 to inhibit ferroptosis and enhance cellular transformation by inducing lipoyltransferase 2 mRNA degradation.
Zhou J, Wang T, Zhang H, Liu J, Wei P, Xu R, Yan Q, Chen G, Li W, Gao SJ, Lu C
PLoS pathogens 2024 Mar;20(3):e1012082
PLoS pathogens 2024 Mar;20(3):e1012082
Sirt6 regulates the proliferation of neural precursor cells and cortical neurogenesis in mice.
Wei Y, Wang X, Ma Z, Xiang P, Liu G, Yin B, Hou L, Shu P, Liu W, Peng X
iScience 2024 Feb 16;27(2):108706
iScience 2024 Feb 16;27(2):108706
N(6)-methyladenosine of Spi2a attenuates inflammation and sepsis-associated myocardial dysfunction in mice.
Wang X, Ding Y, Li R, Zhang R, Ge X, Gao R, Wang M, Huang Y, Zhang F, Zhao B, Liao W, Du J
Nature communications 2023 Mar 2;14(1):1185
Nature communications 2023 Mar 2;14(1):1185
USP17L2-SIRT7 axis regulates DNA damage repair and chemoresistance in breast cancer cells.
Su Y, Wu C, Chang Y, Li L, Chen Y, Jia X, Wang X, Lv Y, Yu B, Yuan J
Breast cancer research and treatment 2022 Nov;196(1):31-44
Breast cancer research and treatment 2022 Nov;196(1):31-44
Aberrant methylmalonylation underlies methylmalonic acidemia and is attenuated by an engineered sirtuin.
Head PE, Myung S, Chen Y, Schneller JL, Wang C, Duncan N, Hoffman P, Chang D, Gebremariam A, Gucek M, Manoli I, Venditti CP
Science translational medicine 2022 May 25;14(646):eabn4772
Science translational medicine 2022 May 25;14(646):eabn4772
Data of RNA-seq transcriptomes of liver, bone, heart, kidney and blood in klotho mice at a pre-symptomatic state and the effect of a traditional Japanese multi-herbal medicine, juzentaihoto.
Okada N, Oshima K, Iwasaki Y, Maruko A, Matsumura K, Iioka E, Vu TD, Fujitsuka N, Nishi A, Sugiyama A, Nishiyama M, Kaneko A, Mizoguchi K, Yamamoto M, Nishimura S
Data in brief 2022 Jun;42:108197
Data in brief 2022 Jun;42:108197
A new FGF1 variant protects against adriamycin-induced cardiotoxicity via modulating p53 activity.
Xiao M, Tang Y, Wang J (a), Lu G, Niu J, Wang J (b), Li J, Liu Q, Wang Z, Huang Z, Guo Y, Gao T, Zhang X, Yue S, Gu J
Redox biology 2022 Feb;49:102219
Redox biology 2022 Feb;49:102219
The prognostic implications of SIRTs expression in breast cancer: a systematic review and meta-analysis.
Zhang H, Ma C, Peng M, Lv X, Xie X, Huang R
Discover oncology 2022 Aug 5;13(1):69
Discover oncology 2022 Aug 5;13(1):69
Influence of psychostimulants and opioids on epigenetic modification of class III histone deacetylase (HDAC)-sirtuins in glial cells.
Sivalingam K, Doke M, Khan MA, Samikkannu T
Scientific reports 2021 Oct 29;11(1):21335
Scientific reports 2021 Oct 29;11(1):21335
Lycorine hydrochloride suppresses stress-induced premature cellular senescence by stabilizing the genome of human cells.
Zhang W, Yang J, Chen Y, Xue R, Mao Z, Lu W, Jiang Y
Aging cell 2021 Feb;20(2):e13307
Aging cell 2021 Feb;20(2):e13307
Intron retention as a new pre-symptomatic marker of aging and its recovery to the normal state by a traditional Japanese multi-herbal medicine.
Okada N, Oshima K, Iwasaki Y, Maruko A, Matsumura K, Iioka E, Vu TD, Fujitsuka N, Nishi A, Sugiyama A, Nishiyama M, Kaneko A, Mizoguchi K, Yamamoto M, Nishimura S
Gene 2021 Aug 20;794:145752
Gene 2021 Aug 20;794:145752
The effects of A549 and H1299 cell-derived exosomes on the proliferation and apoptosis of BEAS-2B cells.
Li Z, Chen X, Yi X
Die Pharmazie 2021 Aug 1;76(8):379-387
Die Pharmazie 2021 Aug 1;76(8):379-387
Sirtuin 7 promotes non‑small cell lung cancer progression by facilitating G1/S phase and epithelial‑mesenchymal transition and activating AKT and ERK1/2 signaling.
Zhao Y, Ye X, Chen R, Gao Q, Zhao D, Ling C, Qian Y, Xu C, Tao M, Xie Y
Oncology reports 2020 Sep;44(3):959-972
Oncology reports 2020 Sep;44(3):959-972
Elevation of JAML Promotes Diabetic Kidney Disease by Modulating Podocyte Lipid Metabolism.
Fu Y, Sun Y, Wang M, Hou Y, Huang W, Zhou D, Wang Z, Yang S, Tang W, Zhen J, Li Y, Wang X, Liu M, Zhang Y, Wang B, Liu G, Yu X, Sun J, Zhang C, Yi F
Cell metabolism 2020 Dec 1;32(6):1052-1062.e8
Cell metabolism 2020 Dec 1;32(6):1052-1062.e8
SIRT7 Regulates Lipopolysaccharide-Induced Inflammatory Injury by Suppressing the NF-κB Signaling Pathway.
Chen KL, Li L, Li CM, Wang YR, Yang FX, Kuang MQ, Wang GL
Oxidative medicine and cellular longevity 2019;2019:3187972
Oxidative medicine and cellular longevity 2019;2019:3187972
Comprehensive Analysis of Expression and Prognostic Value of Sirtuins in Ovarian Cancer.
Sun X, Wang S, Li Q
Frontiers in genetics 2019;10:879
Frontiers in genetics 2019;10:879
SIRT7 depletion inhibits cell proliferation, migration, and increases drug sensitivity by activating p38MAPK in breast cancer cells.
Chen KL, Li L, Yang FX, Li CM, Wang YR, Wang GL
Journal of cellular physiology 2018 Sep;233(9):6767-6778
Journal of cellular physiology 2018 Sep;233(9):6767-6778
Sirt6 deficiency exacerbates podocyte injury and proteinuria through targeting Notch signaling.
Liu M, Liang K, Zhen J, Zhou M, Wang X, Wang Z, Wei X, Zhang Y, Sun Y, Zhou Z, Su H, Zhang C, Li N, Gao C, Peng J, Yi F
Nature communications 2017 Sep 4;8(1):413
Nature communications 2017 Sep 4;8(1):413
MicroRNA-148a deficiency promotes hepatic lipid metabolism and hepatocarcinogenesis in mice.
Cheng L, Zhu Y, Han H, Zhang Q, Cui K, Shen H, Zhang J, Yan J, Prochownik E, Li Y
Cell death & disease 2017 Jul 13;8(7):e2916
Cell death & disease 2017 Jul 13;8(7):e2916
An asymmetrically dimethylarginated nuclear 90 kDa protein (p90aDMA) induced by interleukin (IL)-2, IL-4 or IL-6 in the tumor microenvironment is selectively degraded by autophagy.
Sun L, Xia WY, Zhao SH, Liu N, Liu SS, Xiu P, Li LF, Cao XL, Gao JX
International journal of oncology 2016 Jun;48(6):2461-71
International journal of oncology 2016 Jun;48(6):2461-71
High expression of Sirt7 served as a predictor of adverse outcome in breast cancer.
Geng Q, Peng H, Chen F, Luo R, Li R
International journal of clinical and experimental pathology 2015;8(2):1938-45
International journal of clinical and experimental pathology 2015;8(2):1938-45
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse liver tissue were subjected to SDS PAGE followed by western blot with 12994-1-AP(SIRT7 antibody) at dilution of 1:300
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The SIRT7 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human SIRT7. This antibody recognizes human, mouse, rat antigen. The SIRT7 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
