12994-1-AP

antibody from Proteintech Group

Targeting: SIRT7

Provider product page for 12994-1-AP

Western blot

ELISA

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [38]
Comments [0]
Validations
Western blot [1]
Immunohistochemistry [1]

Submit

Product number: 12994-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#12994-1-AP, RRID:AB_10644276
Product name: SIRT7 antibody
Antibody type: Polyclonal
Description: KD/KO validated SIRT7 antibody (Cat. #12994-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB, ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

SIRT7 protein structure - 12994-1-AP shown in red.

Submitted references Sirt3 Genetically Engineered Apoptotic Bodies Alleviate Skeletal Aging by Limiting Aggravated NLRP3 Inflammasome Activation of Senescent Macrophages.

Wu Y, Ling S, Mao J, Wang H, Wang B, Che Z, Cui W, Cai M
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 May;13(26):e17554

Atrophic Skeletal Muscle-Derived Extracellular Vesicles Transfer miR-125a-5p to Inhibit Bone Formation in Osteoporosis during Aging.

Shao X, Zhang P, Fan Z, Lin J, Chen X, Liu N, Gong W, He Y, Zhou Y, Shi T, Shi Y, Ma Y, Gao W, Wang H, Fang D, Wang C, Wu W, Yan W, Qin J, Chen D, Yu H, Jiang Q, Guo B
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 May;13(25):e15362

SIRT7 facilitates ferroptosis resistance of melanocytes via activating the SMAD3-ATF3-GPX4 signaling pathway in vitiligo.

Wu L, Guo W, Wang H, Yang Y, Zhang H, He L, Chen J, He K, Wang X, Kang P, Chen J, Jiang L, Guo S, Chang Y, Jian Z, Li S, Sato Y, Yamagata K, Gao T, Yi X, Li C
Journal of advanced research 2026 Apr;82:901-916

Sirtuin 7-mediated deacetylation of hypoxia-inducible factor 1-alpha facilitates glycolytic reprogramming and inflammation of keratinocytes in psoriasis.

Luo Y, Su X, Zhang C, Liu Z, Li K, Qiao P, Su C, Xiao C, Li X, Chen J, Wang L, Guo W, Dang E, Wang G, Li B
Journal of advanced research 2026 Apr 14;

Parishin E from ginger-processed Gastrodia elata Bl. alleviates rheumatoid arthritis by regulating histone 3 lactylation at H3K18la and H3K27la sites.

Liu X, Pan Y, Deng C, Zhu M, Guo D, Wu J, Feng F, Pan L, Wang C, Xu K
Frontiers in pharmacology 2025;16:1682504

GLSP mitigates vascular aging by promoting Sirt7-mediated Keap1 deacetylation and Keap1-Nrf2 dissociation.

Cheng Y, Zheng G, Huang H, Ni J, Zhao Y, Sun Y, Chang Y, Liu S, He F, Li D, Guo Y, Miao Y, Xu M, Wang D, Zhang Y, Hua Y, Yang S, Fan G, Ma C
Theranostics 2025;15(10):4345-4367

Acetylation-dependent USP7-TRIM25 axis drives oncogenic progression in non-small cell lung cancer.

Yang J, Chen Z, Hu W, Zeng W, Lei Z, Tong X, Li Q, Luo G, Hu K, Chen Z, Liu Z, Li C, Xu C, Ding C, Zhang HT, Zhao J
Cell death & disease 2025 Oct 6;16(1):695

MiR-148a-3p/SIRT7 axis promotes glioma progression and regulates temozolomide chemosensitivity.

Sun K, Wang J, Gao M, Zhang J, Xu R
Journal of neuro-oncology 2025 Oct 20;176(1):31

SIRT5 mediated succinylation of SUCLA2 regulates TCA cycle dysfunction and mitochondrial damage in pancreatic acinar cells in acute pancreatitis.

Liu W, Wang X, Xu D, Gong F, Pei L, Yang S, Zhao S, Zheng X, Li R, Yang Z, Fei J, Mao E, Chen E, Chen Y
Biochimica et biophysica acta. Molecular basis of disease 2025 Mar;1871(3):167613

Colchicine inhibits vascular calcification by suppressing inflammasome activation through the enhancement of the Sirt2-PP2Ac signaling pathway.

Yang S, Huang H, Jiang K, Peng Y, Liang Z, Gong X, Li L, Li Y, Zhang B, Chen Y, Yang X
The Journal of biological chemistry 2025 Jul;301(7):110381

Blocking of SIRT7/FOXO3a axis by miR-152-3p enhances cisplatin sensitivity in breast cancer.

Shi X, Ji Y, Wu X, Du Y, Yan X, Wang Y, Xia X
The American journal of the medical sciences 2025 Jan;369(1):105-115

SIRT5 regulates granulosa cell proliferation and apoptosis in polycystic ovarian syndrome via desuccinylation of GLI1.

Zhang Y, He F, Cai N, Chen G, Wang Y, Bai W, Guo P
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 2025 Dec;41(1):2515516

Gastrodin regulates H3K14la through the CDT2-KAT2A axis to treat Sepsis-induced myocardial dysfunction.

Yu H, Du Q, Wu J, Feng F, Hou S, Liu M, Wang S, Liu X, Wang C, Xu K
International immunopharmacology 2025 Aug 28;161:115065

Sirt6 Mono-ADP-Ribosylates YY1 to Promote Dystrophin Expression for Neuromuscular Transmission.

Zhang W, Bai L, Xu W, Liu J, Chen Y, Lin W, Lu H, Wang B, Luo B, Peng G, Zhang K, Shen C
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Nov;11(44):e2406390

Sirt7/HIC1 complex participates in hyperglycaemia-mediated EndMT via modulation of SDC1 expression in diabetic kidney disease and metabolic memory.

Lu L, Zhu M, Wu Q, Sun Z, Chen X, Miao C
Journal of cellular and molecular medicine 2024 May;28(9):e18336

KSHV vIL-6 promotes SIRT3-induced deacetylation of SERBP1 to inhibit ferroptosis and enhance cellular transformation by inducing lipoyltransferase 2 mRNA degradation.

Zhou J, Wang T, Zhang H, Liu J, Wei P, Xu R, Yan Q, Chen G, Li W, Gao SJ, Lu C
PLoS pathogens 2024 Mar;20(3):e1012082

Sirt6 regulates the proliferation of neural precursor cells and cortical neurogenesis in mice.

Wei Y, Wang X, Ma Z, Xiang P, Liu G, Yin B, Hou L, Shu P, Liu W, Peng X
iScience 2024 Feb 16;27(2):108706

SIRT7 inhibits the aging and inflammatory damage of hPDLFs by suppressing the AKT/mTOR.

Sun J, Li Y, Meng M, Zeng X, Wang Q, Li W, Luo Y, Chen H, Dong Q
International immunopharmacology 2024 Dec 25;143(Pt 1):113300

NLRP4 renders pancreatic cancer resistant to olaparib through promotion of the DNA damage response and ROS-induced autophagy.

Xiao M, Yang J, Dong M, Mao X, Pan H, Lei Y, Tong X, Yu X, Yu X, Shi S
Cell death & disease 2024 Aug 26;15(8):620

N(6)-methyladenosine of Spi2a attenuates inflammation and sepsis-associated myocardial dysfunction in mice.

Wang X, Ding Y, Li R, Zhang R, Ge X, Gao R, Wang M, Huang Y, Zhang F, Zhao B, Liao W, Du J
Nature communications 2023 Mar 2;14(1):1185

USP17L2-SIRT7 axis regulates DNA damage repair and chemoresistance in breast cancer cells.

Su Y, Wu C, Chang Y, Li L, Chen Y, Jia X, Wang X, Lv Y, Yu B, Yuan J
Breast cancer research and treatment 2022 Nov;196(1):31-44

Aberrant methylmalonylation underlies methylmalonic acidemia and is attenuated by an engineered sirtuin.

Head PE, Myung S, Chen Y, Schneller JL, Wang C, Duncan N, Hoffman P, Chang D, Gebremariam A, Gucek M, Manoli I, Venditti CP
Science translational medicine 2022 May 25;14(646):eabn4772

Data of RNA-seq transcriptomes of liver, bone, heart, kidney and blood in klotho mice at a pre-symptomatic state and the effect of a traditional Japanese multi-herbal medicine, juzentaihoto.

Okada N, Oshima K, Iwasaki Y, Maruko A, Matsumura K, Iioka E, Vu TD, Fujitsuka N, Nishi A, Sugiyama A, Nishiyama M, Kaneko A, Mizoguchi K, Yamamoto M, Nishimura S
Data in brief 2022 Jun;42:108197

A new FGF1 variant protects against adriamycin-induced cardiotoxicity via modulating p53 activity.

Xiao M, Tang Y, Wang J (a), Lu G, Niu J, Wang J (b), Li J, Liu Q, Wang Z, Huang Z, Guo Y, Gao T, Zhang X, Yue S, Gu J
Redox biology 2022 Feb;49:102219

The prognostic implications of SIRTs expression in breast cancer: a systematic review and meta-analysis.

Zhang H, Ma C, Peng M, Lv X, Xie X, Huang R
Discover oncology 2022 Aug 5;13(1):69

Influence of psychostimulants and opioids on epigenetic modification of class III histone deacetylase (HDAC)-sirtuins in glial cells.

Sivalingam K, Doke M, Khan MA, Samikkannu T
Scientific reports 2021 Oct 29;11(1):21335

Lycorine hydrochloride suppresses stress-induced premature cellular senescence by stabilizing the genome of human cells.

Zhang W, Yang J, Chen Y, Xue R, Mao Z, Lu W, Jiang Y
Aging cell 2021 Feb;20(2):e13307

Intron retention as a new pre-symptomatic marker of aging and its recovery to the normal state by a traditional Japanese multi-herbal medicine.

Okada N, Oshima K, Iwasaki Y, Maruko A, Matsumura K, Iioka E, Vu TD, Fujitsuka N, Nishi A, Sugiyama A, Nishiyama M, Kaneko A, Mizoguchi K, Yamamoto M, Nishimura S
Gene 2021 Aug 20;794:145752

The effects of A549 and H1299 cell-derived exosomes on the proliferation and apoptosis of BEAS-2B cells.

Li Z, Chen X, Yi X
Die Pharmazie 2021 Aug 1;76(8):379-387

Sirtuin 7 promotes non‑small cell lung cancer progression by facilitating G1/S phase and epithelial‑mesenchymal transition and activating AKT and ERK1/2 signaling.

Zhao Y, Ye X, Chen R, Gao Q, Zhao D, Ling C, Qian Y, Xu C, Tao M, Xie Y
Oncology reports 2020 Sep;44(3):959-972

Elevation of JAML Promotes Diabetic Kidney Disease by Modulating Podocyte Lipid Metabolism.

Fu Y, Sun Y, Wang M, Hou Y, Huang W, Zhou D, Wang Z, Yang S, Tang W, Zhen J, Li Y, Wang X, Liu M, Zhang Y, Wang B, Liu G, Yu X, Sun J, Zhang C, Yi F
Cell metabolism 2020 Dec 1;32(6):1052-1062.e8

SIRT7 Regulates Lipopolysaccharide-Induced Inflammatory Injury by Suppressing the NF-κB Signaling Pathway.

Chen KL, Li L, Li CM, Wang YR, Yang FX, Kuang MQ, Wang GL
Oxidative medicine and cellular longevity 2019;2019:3187972

Comprehensive Analysis of Expression and Prognostic Value of Sirtuins in Ovarian Cancer.

Sun X, Wang S, Li Q
Frontiers in genetics 2019;10:879

SIRT7 depletion inhibits cell proliferation, migration, and increases drug sensitivity by activating p38MAPK in breast cancer cells.

Chen KL, Li L, Yang FX, Li CM, Wang YR, Wang GL
Journal of cellular physiology 2018 Sep;233(9):6767-6778

Sirt6 deficiency exacerbates podocyte injury and proteinuria through targeting Notch signaling.

Liu M, Liang K, Zhen J, Zhou M, Wang X, Wang Z, Wei X, Zhang Y, Sun Y, Zhou Z, Su H, Zhang C, Li N, Gao C, Peng J, Yi F
Nature communications 2017 Sep 4;8(1):413

MicroRNA-148a deficiency promotes hepatic lipid metabolism and hepatocarcinogenesis in mice.

Cheng L, Zhu Y, Han H, Zhang Q, Cui K, Shen H, Zhang J, Yan J, Prochownik E, Li Y
Cell death & disease 2017 Jul 13;8(7):e2916

An asymmetrically dimethylarginated nuclear 90 kDa protein (p90aDMA) induced by interleukin (IL)-2, IL-4 or IL-6 in the tumor microenvironment is selectively degraded by autophagy.

Sun L, Xia WY, Zhao SH, Liu N, Liu SS, Xiu P, Li LF, Cao XL, Gao JX
International journal of oncology 2016 Jun;48(6):2461-71

High expression of Sirt7 served as a predictor of adverse outcome in breast cancer.

Geng Q, Peng H, Chen F, Luo R, Li R
International journal of clinical and experimental pathology 2015;8(2):1938-45

No comments: Submit comment

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: mouse liver tissue were subjected to SDS PAGE followed by western blot with 12994-1-AP(SIRT7 antibody) at dilution of 1:300
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The SIRT7 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human SIRT7. This antibody recognizes human, mouse, rat antigen. The SIRT7 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Appendix: 12994-1-AP.pdf

: Show more