SIRT7

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. [provided by RefSeq, Jul 2008]

Description

Sirtuin 7

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm, Nuclear speckles

Predicted location

Intracellular

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

17:q25.3 (81911939 - 81921323)

Ensembl ID

ENSG00000187531  (ver. 103.38)

Orthologs

Mouse Sirt7: ENSMUSG00000025138

UniProt

Q9NRC8

neXtProt

NX_Q9NRC8

Human splice variants
Mouse splice variants