Tissue expression
Cell line expression
Protein structure
SF3B1
Splicing factor 3b subunit 1Hsh155, Prp10, PRPF10, SAP155, SF3b155
This gene encodes subunit 1 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. The carboxy-terminal two-thirds of subunit 1 have 22 non-identical, tandem HEAT repeats that form rod-like, helical structures. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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Invitrogen Antibodies | PA5-19679 | 1 references | Polyclonal |
WB
ICC
IHC
OA |
|
Novus Biologicals | NB100-55256 | 1 references | Polyclonal |
WB
IP
IHC
|
|
Boster Biological Technology | A00507-1 | Polyclonal |
WB
ICC
IHC
FC |
||
antibodies-online | ABIN1449241 | 1 references | Monoclonal |
WB
ICC
IP
|
|
LSBio | LS-B11426 | Polyclonal |
WB
EL
IHC
|
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Supportive data in Antibodypedia
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Recommended by provider