Antibody data
- Antibody Data
- Antigen structure
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- Product number
- APG01026G - Provider product page
- Provider
- Leading Biology
- Product name
- FZD7 / Frizzled 7 Antibody (C-Terminus)
- Antibody type
- Polyclonal
- Description
- Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
- Reactivity
- Human, Mouse, Rat, Bovine, Canine, Hamster, Rabbit, Simian
- Host
- Goat
- Storage
- Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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