FZD7

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas. [provided by RefSeq, Jul 2008]

Description

Frizzled class receptor 7

Tissue specificity

Low tissue specificity

Subcell location

Vesicles

Predicted location

Membrane

Protein family

G-protein coupled receptors
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

2 (202033855 - 202038441)

Ensembl ID

ENSG00000155760  (ver. 103.38)

Orthologs

Mouse Fzd7: ENSMUSG00000041075

UniProt

O75084

neXtProt

NX_O75084

Human splice variants
Mouse splice variants

Protein structure