Tissue expression
Cell line expression
Protein structure
CTLA4
Cytotoxic T-lymphocyte associated protein 4CD, CD152, CELIAC3, CTLA-4, GSE, IDDM12
This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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R&D Systems | AF-386-PB | 2 references | Polyclonal |
WB
ICC
FC
|
|
Invitrogen Antibodies | 12-1529-41 | 31 references | Monoclonal |
FC
OA |
|
Novus Biologicals | AF-386-PB | 3 references | Polyclonal |
WB
ICC
FC
|
|
Abnova Corporation | H00001493-M06 | 1 references | Monoclonal |
WB
EL
ICC
|
|
LSBio | LS-C669065 | Monoclonal |
WB
EL
ICC
IHC |
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Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider