BARD1

gene product
This gene encodes a protein which interacts with the N-terminal region of BRCA1. In addition to its ability to bind BRCA1 in vivo and in vitro, it shares homology with the 2 most conserved regions of BRCA1: the N-terminal RING motif and the C-terminal BRCT domain. The RING motif is a cysteine-rich sequence found in a variety of proteins that regulate cell growth, including the products of tumor suppressor genes and dominant protooncogenes. This protein also contains 3 tandem ankyrin repeats. The BARD1/BRCA1 interaction is disrupted by tumorigenic amino acid substitutions in BRCA1, implying that the formation of a stable complex between these proteins may be an essential aspect of BRCA1 tumor suppression. This protein may be the target of oncogenic mutations in breast or ovarian cancer. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]
More gene data

Featured antibodies

Antibodies

 

Filters

Application

Antibodypedia Validation Initiative

Validation method

Reference

Provider

Host

Reactivity

Antibody type

Conjugate

  or   Clear
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider
Validated within AVI
Eligible for validation within AVI
271 antibodies from 31 providers.

Antibody properties

General

Applications

or Cancel
AntibodyRefsTypeWBELICCIPIHCFC
antibodies-online
105 antibodies
Novus Biologicals
4 antibodies
GeneTex
6 antibodies
Affinity Biosciences
1 antibody
Bethyl Laboratories
1 antibody
LifeSpan BioSciences, Inc.
48 antibodies
Biorbyt
18 antibodies
OriGene
4 antibodies
Invitrogen Antibodies
4 antibodies
Abnova Corporation
2 antibodies
Atlas Antibodies
2 antibodies
Bioworld Technology, Inc
1 antibody
Abgent
4 antibodies
NovoPro Bioscience Inc.
2 antibodies
St John's Laboratory
1 antibody
Acris Antibodies GmbH
4 antibodies
Aviva Systems Biology
3 antibodies
Abbkine Scientific Co.Ltd.
1 antibody
Proteintech Group
1 antibody
ProSci
2 antibodies
Abiocode, Inc.
1 antibody
Boster Biological Technology
1 antibody
United States Biological
28 antibodies
Creative Biolabs
4 antibodies
MyBioSource
4 antibodies
GenWay
2 antibodies
RayBiotech, Inc.
2 antibodies
Arigo
1 antibody
EMD Millipore
1 antibody
Sigma-Aldrich
1 antibody