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LearnPA5-13123
antibody from Invitrogen Antibodies
Targeting: GREM1
CKTSF1B1, CRAC1, DAND2, DRM, gremlin, HMPS
Western blot
ImmunohistochemistryAntibody data
- Antibody Data
- Antigen structure
- References [1]
- Comments [0]
- Validations
- Immunohistochemistry [3]
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- Product number
- PA5-13123 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- Anti-GREM1 Polyclonal Antibody
- Antibody type
- Polyclonal
- Antigen
- Synthetic peptide
- Description
- This antibody is predicted to react with non-human primate based on sequence homology.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 400 µL
- Concentration
- 0.5 mg/ml
- Storage
- -20° C, Avoid Freeze/Thaw Cycles
Submitted references BMP signalling in human fetal ovary somatic cells is modulated in a gene-specific fashion by GREM1 and GREM2.
Bayne RA, Donnachie DJ, Kinnell HL, Childs AJ, Anderson RA
Molecular human reproduction 2016 Sep;22(9):622-33
Molecular human reproduction 2016 Sep;22(9):622-33
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Supportive validation
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Immunohistochemistry analysis of ISH and IMH demonstrating gremlin mRNA and gremlin protein in crescentic PECs and tubular epithelial cells of patients with pauci-immune crescentic GN. In comparison with normal renal tissue in which there is no expression of gremlin mRNA (C), proliferating PECs of glomerular crescents show a strong expression of gremlin mRNA by ISH (A); and gremlin protein expression by IMH (B); immune competent infiltrating interstitial cells are also strongly positive for gremlin staining (E); and CTGF was also expressed in these glomerular crescentic cells (F).
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Immunohistochemical analysis of formalin-fixed, paraffin-embedded human skeletal muscle tissue using a GREMLIN polyclonal antibody (Product # PA5-13123), followed by HRP-conjugated secondary antibody and DAB staining.
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Immunohistochemical analysis of formalin-fixed, paraffin-embedded human renal tissue using a GREMLIN polyclonal antibody (Product # PA5-13123) at a dilution of 1:50. Tissues were pretreated with heat-induced epitope retrieval citrate buffer pH 6. 0 in microwave, followed by detection using an ABC system.
