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- Antigen structure
- References [91]
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- Product number
- 66220-1-Ig - Provider product page
- Provider
- Proteintech Group
- Product name
- PD-1/CD279 antibody
- Antibody type
- Monoclonal
- Description
- PD-1/CD279 antibody (Cat. #66220-1-Ig) is a mouse monoclonal antibody that shows reactivity with human, rat, mouse and has been validated for the following applications: FC, IF, IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 4H4D1
- Vial size
- 20ul, 150ul
Submitted references Single-cell transcriptomics unveils the immunologic landscape of anti-PD-1-associated indirect drug-induced liver injury.
Apigenin Sensitizes Melanoma to Chemo/Radiotherapy and Potentiates Immune Killing by Reducing T Cell PD-1 Expression.
A novel proteolysis-targeting chimera strategy targeting multiple immune checkpoints containing ITIMs enhances antitumor immunity.
Chemo-photothermal synergy ignites antitumor immunity via ferroptosis.
Licochalcone B targets neural cell adhesion molecule 1 to inhibit osteosarcoma progression and ferroptosis resistance via extracellular signal-regulated kinase 5 and nuclear factor kappa B pathways.
Adiponectin attenuates atherosclerosis via macrophage polarization-mediated T Cell exhaustion by modulating the NF-κB p65/PI3K/Akt signaling pathway.
Activated T-cell membrane-derived nanocargoes displaying multi-immune checkpoints for enhanced cancer immunotherapy.
Glycyrrhizic acid-loaded biomimetic hybrid liposomes targeting inflammatory cascades and PD-1/PD-L1 pathway to reverse neuroinflammation-driven cognitive decline.
Jianpi-huayu Decotion regulates TREM1/DAP12 pathway to improve the immunosuppressive tumor microenvironment and enhance the anti-hepatocellular carcinoma effect of PD-1 inhibitors.
Identification of a stromal immunosuppressive barrier orchestrated by SPP1(+)/C1QC(+) macrophages and CD8(+) exhausted T cells driving gastric cancer immunotherapy resistance.
Zuojin capsule improves T cell exhaustion and tumor immune microenvironment of hepatocellular carcinoma through the mTOR-eIF4E/p70S6K-CDK1 pathway.
Immune imbalance underlying depressive symptoms in COPD patients: a study based on BDNF, PD-1, MMP-9, and inflammatory cytokines.
Fuhu Lijie Tang treats rheumatoid arthritis through multitarget therapy from autoantigen formation to bone destruction.
Inhibition of ICAM1 diminishes stemness and enhances antitumor immunity in glioblastoma via β-catenin/PD-L1 signaling.
Systematic profiling reveals betaine as an exercise mimetic for geroprotection.
Single-cell multi-omic and spatial profiling of esophageal squamous cell carcinoma reveals the immunosuppressive role of GPR116(+) pericytes in cancer metastasis.
Inhibition of LCP2 in T cells alleviated apoptosis and oxidative stress via PD-1/PD-L1 in diabetic retinopathy.
A Novel Self-Regulated, Non-Directional Magnetic Thermos-Brachytherapy (125)I Seed Enhances Anticancer Efficacy by Rescuing Immune Escape.
Hepatic acetyl-CoA metabolism modulates neuroinflammation and depression susceptibility via acetate.
Simultaneous Electrochemical and Fluorescent In Situ Analysis of PD-1 on Tumor Cells via ZIF-8-Enhanced Quantum Dot Signal Amplification.
PPY-Induced iCAFs Cultivate an Immunosuppressive Microenvironment in Pancreatic Cancer.
Tumor microenvironment-associated oxidative stress impairs SIRT1 secretion to suppress anti-tumor immune response.
Single-Cell Landscape of Bronchoalveolar Lavage Fluid Identifies Specific Neutrophils during Septic Immunosuppression.
Targeting the TRIM21-PD-1 axis potentiates immune checkpoint blockade and CAR-T cell therapy.
Oncogenic activation of SMYD3-SHCBP1 promotes breast cancer development and is coupled with resistance to immune therapy.
Mechanisms of CRLF3-targeted binding to ACTR2 to promote hepatocellular carcinoma progression and effects on the immune microenvironment.
Osteopontin protects from ovalbumin-induced asthma by preserving the microbiome and the intestinal barrier function.
Thermo-responsive nano-hydrogel-based delivery of Saikosaponin a to enhance anti-PD-1 therapy in osteosarcoma.
Targeting SPP1(+) macrophages via the SPP1-CD44 axis reveals a key mechanism of immune suppression and tumor progression in ovarian cancer.
UBE2J1 is identified as a novel plasma cell-related gene involved in the prognosis of high-grade serous ovarian cancer.
Understanding the relationship between silicone implants, tumor antigens, and breast cancer risk: An immunological study in rats.
Tumor-Targeted Delivery of PD-1-Displaying Bacteriophages by Escherichia coli for Adjuvant Treatment of Colorectal Cancer.
PD-1 Attenuates Neuropathic Pain by Ameliorating NLRP3 Inflammasome-Mediated Microglia Pyroptosis.
Ligand-receptor interactions of V-domain Ig-containing suppressor of T cell activation and programmed death-1 suppress the anticancer activities of T cells.
PD-1/PD-L1 pathway relieves incision induced acute postoperative pain via inhibiting the neuroinflammation in dorsal root ganglion of rats.
Ara-C suppresses H3 K27-altered spinal cord diffuse midline glioma growth and enhances immune checkpoint blockade sensitivity.
Radix Bupleuri-Radix Paeoniae Alba Inhibits the Development of Hepatocellular Carcinoma through Activation of the PTEN/PD-L1 Axis within the Immune Microenvironment.
Role of vascular endothelial growth factor D in lung adenocarcinoma immunotherapy response.
Subtype-specific human endogenous retrovirus K102 envelope protein is a novel serum immunosuppressive biomarker of cancer.
HMGB2 drives tumor progression and shapes the immunosuppressive microenvironment in hepatocellular carcinoma: insights from multi-omics analysis.
BAP1 regulates HSF1 activity and cancer immunity in pancreatic cancer.
H3K9 lactylation in malignant cells facilitates CD8(+) T cell dysfunction and poor immunotherapy response.
Vimentin, inversely correlating with infiltration of CD8 + T lymphocytes, promotes nuclear translocation of PD-L1 in esophageal squamous cell carcinoma.
Tumor-colonized Streptococcus mutans metabolically reprograms tumor microenvironment and promotes oral squamous cell carcinoma.
High PD-1 and CTLA-4 expression correlates with host immune suppression in patients and a mouse model infected with Echinococcus multilocularis.
Myeloid gasdermin D drives early-stage T cell immunity and peripheral inflammation in a mouse model of Alzheimer's disease.
Exogenous PD-L1 binds to PD-1 to alleviate and prevent autism-like behaviors in maternal immune activation-induced male offspring mice.
HMGB1 promotes neutrophil PD-L1 expression through TLR2 and mediates T cell apoptosis leading to immunosuppression in sepsis.
PD-1/PD-L1 axis is involved in the interaction between microglial polarization and glioma.
EGCG suppresses PD-1 expression of T cells via inhibiting NF-κB phosphorylation and nuclear translocation.
STING activation reprograms the microenvironment to sensitize NF1-related malignant peripheral nerve sheath tumors for immunotherapy.
Prognostic significance and immunological role of HPRT1 in human cancers.
Metabolic landscape of head and neck squamous cell carcinoma informs a novel kynurenine/Siglec-15 axis in immune escape.
Pan-Cancer Single-Cell and Spatial-Resolved Profiling Reveals the Immunosuppressive Role of APOE+ Macrophages in Immune Checkpoint Inhibitor Therapy.
Chemokine‑ and chemokine receptor-based subtypes predict prognosis, immunotherapy and chemotherapy response in colorectal cancer patients.
Surface PD-1 expression in T cells is suppressed by HNRNPK through an exonic splicing silencer on exon 3.
The single cell immunogenomic landscape after neoadjuvant immunotherapy combined chemotherapy in esophageal squamous cell carcinoma.
An anti-PD-1 antisense oligonucleotide promotes the expression of soluble PD-1 by blocking the interaction between SRSF3 and an exonic splicing enhancer of PD-1 exon 3.
Extra villous trophoblast-derived PDL1 can ameliorate macrophage inflammation and promote immune adaptation associated with preeclampsia.
Integrated-omics profiling unveils the disparities of host defense to ECM scaffolds during wound healing in aged individuals.
Optimal timing of anti-PD-1 antibody combined with chemotherapy administration in patients with NSCLC.
The deubiquitinase USP2a promotes tumor immunosuppression by stabilizing immune checkpoint B7-H4 in lung adenocarcinoma harboring EGFR-activating mutants.
Anti-PD-1 treatment protects against seizure by suppressing sodium channel function.
C. tropicalis promotes CRC by down-regulating tumor cell-intrinsic PD-1 receptor via autophagy.
PD1 is transcriptionally regulated by LEF1 in mature T cells.
Effects of Nanosecond Pulsed Electric Field on Immune Checkpoint Receptors in Melanoma Cells.
Extracellular nicotinamide phosphoribosyltransferase (eNAMPT) neutralization counteracts T cell immune evasion in breast cancer.
Attenuated Salmonella-delivered PD-1 siRNA enhances the antitumor effects of EZH2 inhibitors in colorectal cancer.
Electroacupuncture Alleviates CFA-Induced Inflammatory Pain via PD-L1/PD-1-SHP-1 Pathway.
Warming Menstruation and Analgesic Soup Inhibits PD-1/PD-L1 Pathway in Rats with Endometriosis.
ERK and USP5 govern PD-1 homeostasis via deubiquitination to modulate tumor immunotherapy.
Targeting HMGA1 contributes to immunotherapy in aggressive breast cancer while suppressing EMT.
Interaction of immune checkpoint PD-1 and chemokine receptor 4 (CXCR4) promotes a malignant phenotype in pancreatic cancer cells.
Transcriptomic analysis of graft liver provides insight into the immune response of rat liver transplantation.
Identification and experimental validation of a tumor-infiltrating lymphocytes-related long noncoding RNA signature for prognosis of clear cell renal cell carcinoma.
Anemoside B4 ameliorates experimental autoimmune encephalomyelitis in mice by modulating inflammatory responses and the gut microbiota.
Anemoside B4 protects against chronic relapsing colitis in mice by modulating inflammatory response, colonic transcriptome and the gut microbiota.
PD-1 engineered cytomembrane cloaked molybdenum nitride for synergistic photothermal and enhanced immunotherapy of breast cancer.
Overexpression of Programmed Cell Death 1 Prevents Doxorubicin-Induced Apoptosis Through Autophagy Induction in H9c2 Cardiomyocytes.
Glutamine deprivation impairs function of infiltrating CD8(+) T cells in hepatocellular carcinoma by inducing mitochondrial damage and apoptosis.
The immunomodulatory effect of microglia on ECM neuroinflammation via the PD-1/PD-L1 pathway.
CMTM6: increased circulating level and up-regulated expression in labial salivary glands in patients with primary Sjogren's syndrome.
Overcoming PD-1 Inhibitor Resistance with a Monoclonal Antibody to Secreted Frizzled-Related Protein 2 in Metastatic Osteosarcoma.
The mRNA expression of Il6 and Pdcd1 are predictive and protective factors for doxorubicin‑induced cardiotoxicity.
Targeted elimination of myeloid-derived suppressor cells via regulation of the STAT pathway alleviates tumor immunosuppression in neuroblastoma.
Elevated lymphocyte specific protein 1 expression is involved in the regulation of leukocyte migration and immunosuppressive microenvironment in glioblastoma.
Berberine Maintains the Neutrophil N1 Phenotype to Reverse Cancer Cell Resistance to Doxorubicin.
Survival analysis with regard to PD-L1 and CD155 expression in human small cell lung cancer and a comparison with associated receptors.
m(6)A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade.
Programmed cell death ligand 1 (PD-L1) expression is not a predominant feature in Ewing sarcomas.
Impact of mismatch-repair deficiency on the colorectal cancer immune microenvironment.
Wu J, Miao H, Yuan W, Yao Y, Zhou D, Jiang K, Yang X, Xiong M, Gan D, Lu Y, Liu A, Luo Y, Liu Z, Luo D
Journal of gastroenterology 2026 May;61(5):603-624
Journal of gastroenterology 2026 May;61(5):603-624
Apigenin Sensitizes Melanoma to Chemo/Radiotherapy and Potentiates Immune Killing by Reducing T Cell PD-1 Expression.
Yang G, Lv J, Dai M, Zhang Y, Long Y, Wang F, Zaky MY, Zhang Y, Liu H, Liu S, Zhang Y, Hu Z, Xu L
Phytotherapy research : PTR 2026 May;40(5):2197-2209
Phytotherapy research : PTR 2026 May;40(5):2197-2209
A novel proteolysis-targeting chimera strategy targeting multiple immune checkpoints containing ITIMs enhances antitumor immunity.
Qiu YY, Wang ZW, He L, Shi GG, Li ZZ, Ma SX, Yu D, Du HC, Xie F, Zhang C, Zhang YQ, Li M, Li WN
Journal of pharmaceutical analysis 2026 Mar;16(3):101511
Journal of pharmaceutical analysis 2026 Mar;16(3):101511
Chemo-photothermal synergy ignites antitumor immunity via ferroptosis.
Lin J, Yang H, Zou Z, Deng L, Cai X, Chen M, Xu J, Yin W, Wen B, Xie W, Xu Q, Zhong G, Wu Z, Chen Y, Zhang R, Tian W, Zhang Y, Long Y, Li Y, Han Z, Liang Y, Ye J, Lu J, Liang Y, Dai Q, Zou F, He H, Zhong W, Zhuo Y
Signal transduction and targeted therapy 2026 Mar 17;11(1)
Signal transduction and targeted therapy 2026 Mar 17;11(1)
Licochalcone B targets neural cell adhesion molecule 1 to inhibit osteosarcoma progression and ferroptosis resistance via extracellular signal-regulated kinase 5 and nuclear factor kappa B pathways.
Wang S, Liang F, Wei H, Huang X, Lin H, Chen F, Lin R, Huang Z, Lin J, Wu Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157584
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157584
Adiponectin attenuates atherosclerosis via macrophage polarization-mediated T Cell exhaustion by modulating the NF-κB p65/PI3K/Akt signaling pathway.
Qin M, Xu S, Chen Y, Luo X, Tang X, Zhang L, Xu Q
Tissue & cell 2026 Feb;98:103150
Tissue & cell 2026 Feb;98:103150
Activated T-cell membrane-derived nanocargoes displaying multi-immune checkpoints for enhanced cancer immunotherapy.
Du L, Zhang X, Gong Y, Liu M, Sun J, Hu X, Peng J, Liu Z, Zhang T, Xu J, Gao F, Cheng W
Materials today. Bio 2026 Feb;36:102702
Materials today. Bio 2026 Feb;36:102702
Glycyrrhizic acid-loaded biomimetic hybrid liposomes targeting inflammatory cascades and PD-1/PD-L1 pathway to reverse neuroinflammation-driven cognitive decline.
Wang Y, Luo F, Zhang P, Niu H, Tan Y, Zhang Y, Tang Z, Du L, Jin Y, Jin X
Materials today. Bio 2026 Feb;36:102657
Materials today. Bio 2026 Feb;36:102657
Jianpi-huayu Decotion regulates TREM1/DAP12 pathway to improve the immunosuppressive tumor microenvironment and enhance the anti-hepatocellular carcinoma effect of PD-1 inhibitors.
Yao R, Zhang Y, Yu W, Chen X, Shi H, Luo R, Fang C, Zhao X, Zhu X, Lai Y, Xiao S, Chen Y, Zhang J, Zhong C
Journal of ethnopharmacology 2026 Feb 10;356:120846
Journal of ethnopharmacology 2026 Feb 10;356:120846
Identification of a stromal immunosuppressive barrier orchestrated by SPP1(+)/C1QC(+) macrophages and CD8(+) exhausted T cells driving gastric cancer immunotherapy resistance.
Ma G, Liu X, Jiang Q, Li S, Wu Q, Liang B, Sun F, Gu C, Liao W, Zhang Z, Shi M, Huang Q
Frontiers in immunology 2025;16:1618591
Frontiers in immunology 2025;16:1618591
Zuojin capsule improves T cell exhaustion and tumor immune microenvironment of hepatocellular carcinoma through the mTOR-eIF4E/p70S6K-CDK1 pathway.
Hao L, Li S, Deng J, Hu X
Frontiers in immunology 2025;16:1617604
Frontiers in immunology 2025;16:1617604
Immune imbalance underlying depressive symptoms in COPD patients: a study based on BDNF, PD-1, MMP-9, and inflammatory cytokines.
Liu S, Dong J, Huang W, Yan J
Frontiers in medicine 2025;12:1606630
Frontiers in medicine 2025;12:1606630
Fuhu Lijie Tang treats rheumatoid arthritis through multitarget therapy from autoantigen formation to bone destruction.
Yao Z, He J, Hu M, Yan P, Xu Q, Zhang Q, Lin Y, Liao J, Cai X, Liu L
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Sep;145:157086
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Sep;145:157086
Inhibition of ICAM1 diminishes stemness and enhances antitumor immunity in glioblastoma via β-catenin/PD-L1 signaling.
Guo M, Yuan Z, Jin X, Li X, Deng Y, Zhou S, Niu R, Bae J, Park JB, Shi B, Yin J
Nature communications 2025 Sep 30;16(1):8642
Nature communications 2025 Sep 30;16(1):8642
Systematic profiling reveals betaine as an exercise mimetic for geroprotection.
Geng L, Ping J, Wu R, Yan H, Zhang H, Zhuang Y, Ning T, Wang J, Liang C, Zhang J, Chu Q, Zhang J, Wen Y, Jing Y, Sun S, Qiao Q, Zhao Q, Ji Q, Ma S, Cai Y, Zheng Y, Zou Z, Diao Z, Li M, Zhang H, Hu J, Fu L, Kang W, Bai R, Zhao H, Zhang S, Ding Y, Lei J, Wang W, Ji Y, Gou B, Sun G, Yin J, Yan P, Li H, Wang Z, Ma S, Liu Z, Shan H, Wang Q, Cao T, Yang S, Wang C, Yang P, Fan Y, Ye Y, Hu J, Jiang M, Wang Y, Liu K, Li Y, Li Y, Li J, Ci W, Jin ZB, Fu X, Zhang X, Zhao G, Izpisua Belmonte JC, Wang S, Song M, Zhang W, Qu J, Liu GH
Cell 2025 Sep 18;188(19):5403-5425.e33
Cell 2025 Sep 18;188(19):5403-5425.e33
Single-cell multi-omic and spatial profiling of esophageal squamous cell carcinoma reveals the immunosuppressive role of GPR116(+) pericytes in cancer metastasis.
Pei X, Liu Z, Tang L, Zhang J, He Y, Zhuang X, Song Y, Peng S, He Y, Zhao Y, Huang X, Xu Y, Li J, Peng L, Shi X, Zhang F, Liu C, He M, Dai W, Wu L, Law S, Liu J, Wang Z, Li Z, Xu W, Liu Z, Li B
Nature genetics 2025 Oct;57(10):2494-2508
Nature genetics 2025 Oct;57(10):2494-2508
Inhibition of LCP2 in T cells alleviated apoptosis and oxidative stress via PD-1/PD-L1 in diabetic retinopathy.
Lu M, Ye X, Deng X, Jiao F, Ren H, Xing Y
International immunopharmacology 2025 Oct 10;163:115240
International immunopharmacology 2025 Oct 10;163:115240
A Novel Self-Regulated, Non-Directional Magnetic Thermos-Brachytherapy (125)I Seed Enhances Anticancer Efficacy by Rescuing Immune Escape.
Xu B, Wu YM, Cheng YF, Dong L, Ding SW, Chen SR, Chen BD, Yang RP, Zhang WH, Wang YJ, Mao WP, Shi F, Jin ZC, Chen JJ, Qiao EQ, Wang YQ, Li JZ, Zeng P, Wu CW, Zhang W, Xie JB, Lu J, Teng GJ
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Nov;12(43):e08091
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Nov;12(43):e08091
Hepatic acetyl-CoA metabolism modulates neuroinflammation and depression susceptibility via acetate.
Cao Y, Zhao Y, Deng T, Zhou Q, Hu G, Hu ZL, Jiang YY, Yang XH, Wang F, Wu PF, Chen JG
Cell metabolism 2025 Nov 4;37(11):2185-2201.e8
Cell metabolism 2025 Nov 4;37(11):2185-2201.e8
Simultaneous Electrochemical and Fluorescent In Situ Analysis of PD-1 on Tumor Cells via ZIF-8-Enhanced Quantum Dot Signal Amplification.
Zhang Z, Li X, Zhang S, Zheng M, Yuan F, Li S, Yuan B, Liu L, Du X
ACS sensors 2025 Nov 28;10(11):8829-8838
ACS sensors 2025 Nov 28;10(11):8829-8838
PPY-Induced iCAFs Cultivate an Immunosuppressive Microenvironment in Pancreatic Cancer.
Cao M, Peng W, Cheng B, Wang R, Chen W, Liu L, Huang H, Chen S, Cui H, Liang J, Zhou Q, Xiong S, Bai S, Liu L, Zhao Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 May;12(20):e2413432
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 May;12(20):e2413432
Tumor microenvironment-associated oxidative stress impairs SIRT1 secretion to suppress anti-tumor immune response.
Wang Z, Guo W, Zhang X, Wei Y, Zhang W, Du N, Li C, Wu X, Yi F, Zhou T, Dong X, Guo Q, Xu H, Wang E, Li N, Cheng R, Li Z, Song X, Sun Y, Sun X, Cao L
Cell reports 2025 May 27;44(5):115679
Cell reports 2025 May 27;44(5):115679
Single-Cell Landscape of Bronchoalveolar Lavage Fluid Identifies Specific Neutrophils during Septic Immunosuppression.
Shen R, Jiang Y, Liu G, Gao S, Sun H, Wu X, Gu J, Wu H, Mo K, Niu X, Ben-Ami R, Shang W, Zhang J, Wang J, Miao C, Wang Z, Chen W
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Mar;12(11):e2406218
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Mar;12(11):e2406218
Targeting the TRIM21-PD-1 axis potentiates immune checkpoint blockade and CAR-T cell therapy.
Shi J, Zhang Z, Chen HY, Yao Y, Ke S, Yu K, Shi J, Xiao X, He C, Xiang B, Sun Y, Gao M, Xing X, Yu H, Wang X, Yuan WC, Budiarto BR, Chen SY, Zhang T, Lee YR, Zhu H, Zhang J
Molecular therapy : the journal of the American Society of Gene Therapy 2025 Mar 5;33(3):1073-1090
Molecular therapy : the journal of the American Society of Gene Therapy 2025 Mar 5;33(3):1073-1090
Oncogenic activation of SMYD3-SHCBP1 promotes breast cancer development and is coupled with resistance to immune therapy.
Mo L, Deng M, Adhav R, Chan Y, Lei JH, Su SM, Zhang X, An T, Liu J, Li J, Shu X, Xu J, Wang Y, Chen L, Man YG, Shao NY, Xiang T, Deng CX, Xu X
Cell death & disease 2025 Mar 29;16(1):220
Cell death & disease 2025 Mar 29;16(1):220
Mechanisms of CRLF3-targeted binding to ACTR2 to promote hepatocellular carcinoma progression and effects on the immune microenvironment.
Ye S, Zhang X, Liu F, Niu Q, Liu A, Xia D
Cytotechnology 2025 Jun;77(3):113
Cytotechnology 2025 Jun;77(3):113
Osteopontin protects from ovalbumin-induced asthma by preserving the microbiome and the intestinal barrier function.
Huang J, Qiao H, Li Q, Zhang Y, Zhang C, Su H, Sun X
mSystems 2025 Jun 17;10(6):e0038925
mSystems 2025 Jun 17;10(6):e0038925
Thermo-responsive nano-hydrogel-based delivery of Saikosaponin a to enhance anti-PD-1 therapy in osteosarcoma.
Chen YQ, Yang D, Li K, Liu JS, Feng HJ, Zhou JW
Nanomedicine (London, England) 2025 Jul;20(14):1677-1691
Nanomedicine (London, England) 2025 Jul;20(14):1677-1691
Targeting SPP1(+) macrophages via the SPP1-CD44 axis reveals a key mechanism of immune suppression and tumor progression in ovarian cancer.
Hou L, Jiang M, Li Y, Cheng J, Liu F, Han X, Guo J, Feng L, Li Z, Yi J, Zhao X, Gao Y, Yue W
International immunopharmacology 2025 Jul 28;160:114906
International immunopharmacology 2025 Jul 28;160:114906
UBE2J1 is identified as a novel plasma cell-related gene involved in the prognosis of high-grade serous ovarian cancer.
Tian Y, Dong R, Guan Y, Wang Y, Zhao W, Zhang J, Kang S
Journal of translational medicine 2025 Jan 28;23(1):129
Journal of translational medicine 2025 Jan 28;23(1):129
Understanding the relationship between silicone implants, tumor antigens, and breast cancer risk: An immunological study in rats.
Zhou Y, Li Z, Wang G, Yu H, Zhou Y, Li Y, Chen W, Dai H, He Y, Li L
International immunopharmacology 2025 Feb 6;147:113991
International immunopharmacology 2025 Feb 6;147:113991
Tumor-Targeted Delivery of PD-1-Displaying Bacteriophages by Escherichia coli for Adjuvant Treatment of Colorectal Cancer.
Li HR, Zhou Y, Ye BC
ACS synthetic biology 2025 Feb 21;14(2):407-419
ACS synthetic biology 2025 Feb 21;14(2):407-419
PD-1 Attenuates Neuropathic Pain by Ameliorating NLRP3 Inflammasome-Mediated Microglia Pyroptosis.
Deng D, Ma L, Shen J, Huang L, Zhang T, Yang X, Huang S, Zhao W, Zhou Y, Fan S, Wang K, Chen X
Molecular neurobiology 2025 Dec;62(12):15478-15493
Molecular neurobiology 2025 Dec;62(12):15478-15493
Ligand-receptor interactions of V-domain Ig-containing suppressor of T cell activation and programmed death-1 suppress the anticancer activities of T cells.
Abooali M, Lei X, Yasinska IM, Schlichtner S, Hussain R, Siligardi G, Gianga TM, Berger SM, Cholewa D, Gibbs BF, Fasler-Kan E, Sumbayev VV
Immuno-oncology technology 2025 Dec;28:101533
Immuno-oncology technology 2025 Dec;28:101533
PD-1/PD-L1 pathway relieves incision induced acute postoperative pain via inhibiting the neuroinflammation in dorsal root ganglion of rats.
Zhang H, Wang Y, Wen S, Li J
Scientific reports 2025 Dec 17;16(1):2007
Scientific reports 2025 Dec 17;16(1):2007
Ara-C suppresses H3 K27-altered spinal cord diffuse midline glioma growth and enhances immune checkpoint blockade sensitivity.
Pang B, Wu Y, An S, Chang Y, Yan H, Lin H, Zhao Z, Wu F, Chang Q, Jia W, Jiang T, Wang Y, Chai R
Science advances 2025 Apr 18;11(16):eadu3956
Science advances 2025 Apr 18;11(16):eadu3956
Radix Bupleuri-Radix Paeoniae Alba Inhibits the Development of Hepatocellular Carcinoma through Activation of the PTEN/PD-L1 Axis within the Immune Microenvironment.
Zhang F, Zhou K, Yuan W, Sun K
Nutrition and cancer 2024;76(1):63-79
Nutrition and cancer 2024;76(1):63-79
Role of vascular endothelial growth factor D in lung adenocarcinoma immunotherapy response.
Du X, Yang S, Bian J, Zhang Y, Wang Y, Lv Z
American journal of translational research 2024;16(6):2263-2277
American journal of translational research 2024;16(6):2263-2277
Subtype-specific human endogenous retrovirus K102 envelope protein is a novel serum immunosuppressive biomarker of cancer.
Gong Q, Xu R
Frontiers in immunology 2024;15:1533740
Frontiers in immunology 2024;15:1533740
HMGB2 drives tumor progression and shapes the immunosuppressive microenvironment in hepatocellular carcinoma: insights from multi-omics analysis.
Chen YZ, Meng ZS, Xiang ZL
Frontiers in immunology 2024;15:1415435
Frontiers in immunology 2024;15:1415435
BAP1 regulates HSF1 activity and cancer immunity in pancreatic cancer.
Yuan W, Zhang Q, Zhao Y, Xia W, Yin S, Liang X, Chen T, Li G, Liu Y, Liu Z, Huang J
Journal of experimental & clinical cancer research : CR 2024 Sep 30;43(1):275
Journal of experimental & clinical cancer research : CR 2024 Sep 30;43(1):275
H3K9 lactylation in malignant cells facilitates CD8(+) T cell dysfunction and poor immunotherapy response.
Wang R, Li C, Cheng Z, Li M, Shi J, Zhang Z, Jin S, Ma H
Cell reports 2024 Sep 24;43(9):114686
Cell reports 2024 Sep 24;43(9):114686
Vimentin, inversely correlating with infiltration of CD8 + T lymphocytes, promotes nuclear translocation of PD-L1 in esophageal squamous cell carcinoma.
Liang Y, He S, Liu Q, Liu T, Tan Y, Peng T, Huang C, Lu X, Zheng S
Biochimica et biophysica acta. Molecular cell research 2024 Oct;1871(7):119781
Biochimica et biophysica acta. Molecular cell research 2024 Oct;1871(7):119781
Tumor-colonized Streptococcus mutans metabolically reprograms tumor microenvironment and promotes oral squamous cell carcinoma.
Zhou J, Hu Z, Wang L, Hu Q, Chen Z, Lin T, Zhou R, Cai Y, Wu Z, Zhang Z, Yang Y, Zhang C, Li G, Zeng L, Su K, Li H, Su Q, Zeng G, Cheng B, Wu T
Microbiome 2024 Oct 5;12(1):193
Microbiome 2024 Oct 5;12(1):193
High PD-1 and CTLA-4 expression correlates with host immune suppression in patients and a mouse model infected with Echinococcus multilocularis.
Sun T, Yang Y, Qiu Y, Wang T, Yang M, Shen S, Wang W
Parasites & vectors 2024 Oct 25;17(1):437
Parasites & vectors 2024 Oct 25;17(1):437
Myeloid gasdermin D drives early-stage T cell immunity and peripheral inflammation in a mouse model of Alzheimer's disease.
Rui W, Wu Y, Yang Y, Xie W, Qin D, Ming J, Ye Z, Lu L, Zong M, Tang X, Fan L, Li S
Journal of neuroinflammation 2024 Oct 19;21(1):266
Journal of neuroinflammation 2024 Oct 19;21(1):266
Exogenous PD-L1 binds to PD-1 to alleviate and prevent autism-like behaviors in maternal immune activation-induced male offspring mice.
Zeng X, Fan L, Qin Q, Zheng D, Wang H, Li M, Jiang Y, Wang H, Liu H, Liang S, Wu L, Liang S
Brain, behavior, and immunity 2024 Nov;122:527-546
Brain, behavior, and immunity 2024 Nov;122:527-546
HMGB1 promotes neutrophil PD-L1 expression through TLR2 and mediates T cell apoptosis leading to immunosuppression in sepsis.
Liu J, Song K, Lin B, Chen Z, Zuo Z, Fang Y, He Q, Yao X, Liu Z, Huang Q, Guo X
International immunopharmacology 2024 May 30;133:112130
International immunopharmacology 2024 May 30;133:112130
PD-1/PD-L1 axis is involved in the interaction between microglial polarization and glioma.
Wang XP, Guo W, Chen YF, Hong C, Ji J, Zhang XY, Dong YF, Sun XL
International immunopharmacology 2024 May 30;133:112074
International immunopharmacology 2024 May 30;133:112074
EGCG suppresses PD-1 expression of T cells via inhibiting NF-κB phosphorylation and nuclear translocation.
Li ZD, Liu F, Zeng Y, Liu Y, Luo W, Yuan F, Li S, Li Q, Chen J, Fujita M, Zhang G, Li Y
International immunopharmacology 2024 May 30;133:112069
International immunopharmacology 2024 May 30;133:112069
STING activation reprograms the microenvironment to sensitize NF1-related malignant peripheral nerve sheath tumors for immunotherapy.
Somatilaka BN, Madana L, Sadek A, Chen Z, Chandrasekaran S, McKay RM, Le LQ
The Journal of clinical investigation 2024 Mar 19;134(10)
The Journal of clinical investigation 2024 Mar 19;134(10)
Prognostic significance and immunological role of HPRT1 in human cancers.
Lu Y, Chen R, Zhang H, Sun X, Li X, Yang M, Zhang X
Biomolecules & biomedicine 2024 Mar 11;24(2):262-291
Biomolecules & biomedicine 2024 Mar 11;24(2):262-291
Metabolic landscape of head and neck squamous cell carcinoma informs a novel kynurenine/Siglec-15 axis in immune escape.
Zhang XY, Shi JB, Jin SF, Wang RJ, Li MY, Zhang ZY, Yang X, Ma HL
Cancer communications (London, England) 2024 Jun;44(6):670-694
Cancer communications (London, England) 2024 Jun;44(6):670-694
Pan-Cancer Single-Cell and Spatial-Resolved Profiling Reveals the Immunosuppressive Role of APOE+ Macrophages in Immune Checkpoint Inhibitor Therapy.
Liu C, Xie J, Lin B, Tian W, Wu Y, Xin S, Hong L, Li X, Liu L, Jin Y, Tang H, Deng X, Zou Y, Zheng S, Fang W, Cheng J, Dai X, Bao X, Zhao P
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Jun;11(23):e2401061
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Jun;11(23):e2401061
Chemokine‑ and chemokine receptor-based subtypes predict prognosis, immunotherapy and chemotherapy response in colorectal cancer patients.
Zhu W, Zhao S, Cheng X, Wu C, Liu Z, Huang J
International immunopharmacology 2024 Jun 15;134:112172
International immunopharmacology 2024 Jun 15;134:112172
Surface PD-1 expression in T cells is suppressed by HNRNPK through an exonic splicing silencer on exon 3.
Wang J, Yan L, Wang X, Jia R, Guo J
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2024 Jul;73(7):1123-1135
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2024 Jul;73(7):1123-1135
The single cell immunogenomic landscape after neoadjuvant immunotherapy combined chemotherapy in esophageal squamous cell carcinoma.
Wang Z, Zhao Y, Wo Y, Peng Y, Hu W, Wu Z, Liu P, Shang Y, Liu C, Chen X, Huang K, Chen Y, Hong H, Li F, Sun Y
Cancer letters 2024 Jul 1;593:216951
Cancer letters 2024 Jul 1;593:216951
An anti-PD-1 antisense oligonucleotide promotes the expression of soluble PD-1 by blocking the interaction between SRSF3 and an exonic splicing enhancer of PD-1 exon 3.
Wang X, Yan L, Guo J, Jia R
International immunopharmacology 2024 Jan 5;126:111280
International immunopharmacology 2024 Jan 5;126:111280
Extra villous trophoblast-derived PDL1 can ameliorate macrophage inflammation and promote immune adaptation associated with preeclampsia.
Cui Y, Wu S, Liu K, Zhao H, Ma B, Gong L, Zhou Q, Li X
Journal of reproductive immunology 2024 Feb;161:104186
Journal of reproductive immunology 2024 Feb;161:104186
Integrated-omics profiling unveils the disparities of host defense to ECM scaffolds during wound healing in aged individuals.
Chen SD, Chu CY, Wang CB, Yang Y, Xu ZY, Qu YL, Man Y
Biomaterials 2024 Dec;311:122685
Biomaterials 2024 Dec;311:122685
Optimal timing of anti-PD-1 antibody combined with chemotherapy administration in patients with NSCLC.
Huo Y, Wang D, Yang S, Xu Y, Qin G, Zhao C, Lei Q, Zhao Q, Liu Y, Guo K, Ouyang S, Sun T, Wang H, Fan F, Han N, Liu H, Chen H, Miao L, Liu L, Duan Y, Lv W, Liu L, Zhang Z, Cang S, Wang L, Zhang Y
Journal for immunotherapy of cancer 2024 Dec 19;12(12)
Journal for immunotherapy of cancer 2024 Dec 19;12(12)
The deubiquitinase USP2a promotes tumor immunosuppression by stabilizing immune checkpoint B7-H4 in lung adenocarcinoma harboring EGFR-activating mutants.
Lu Y, Sun Y, Zhang J, Kong M, Zhao Z, Sun B, Wang Y, Jiang Y, Chen S, Wang C, Tong Y, Wen L, Huang M, Wu F, Zhang L
Cancer letters 2024 Aug 1;596:217020
Cancer letters 2024 Aug 1;596:217020
Anti-PD-1 treatment protects against seizure by suppressing sodium channel function.
Yang Y, Chen Z, Zhou J, Jiang S, Wang G, Wan L, Yu J, Jiang M, Wang Y, Hu J, Liu X, Wang Y
CNS neuroscience & therapeutics 2024 Apr;30(4):e14504
CNS neuroscience & therapeutics 2024 Apr;30(4):e14504
C. tropicalis promotes CRC by down-regulating tumor cell-intrinsic PD-1 receptor via autophagy.
Qu J, Chen Q, Bing Z, Shen S, Hou Y, Lv M, Wang T
Journal of Cancer 2023;14(10):1794-1808
Journal of Cancer 2023;14(10):1794-1808
PD1 is transcriptionally regulated by LEF1 in mature T cells.
Zhao P, Sun L, Zhao C, Malik S
Immunobiology 2023 Sep;228(5):152708
Immunobiology 2023 Sep;228(5):152708
Effects of Nanosecond Pulsed Electric Field on Immune Checkpoint Receptors in Melanoma Cells.
Sauer N, Szlasa W, Szewczyk A, Novickij V, Saczko J, Baczyńska D, Daczewska M, Kulbacka J
Pharmaceuticals (Basel, Switzerland) 2023 Sep 27;16(10)
Pharmaceuticals (Basel, Switzerland) 2023 Sep 27;16(10)
Extracellular nicotinamide phosphoribosyltransferase (eNAMPT) neutralization counteracts T cell immune evasion in breast cancer.
Travelli C, Colombo G, Aliotta M, Fagiani F, Fava N, De Sanctis R, Grolla AA, Garcia JGN, Clemente N, Portararo P, Costanza M, Condorelli F, Colombo MP, Sangaletti S, Genazzani AA
Journal for immunotherapy of cancer 2023 Oct;11(10)
Journal for immunotherapy of cancer 2023 Oct;11(10)
Attenuated Salmonella-delivered PD-1 siRNA enhances the antitumor effects of EZH2 inhibitors in colorectal cancer.
Lv M, Guo S, Zhang X, Zou Y, Chen Q, Zang C, Huang S, Hu Y, Wang Y, Wang Q, Zhong J
International immunopharmacology 2023 Nov;124(Pt A):110918
International immunopharmacology 2023 Nov;124(Pt A):110918
Electroacupuncture Alleviates CFA-Induced Inflammatory Pain via PD-L1/PD-1-SHP-1 Pathway.
Deng D, Xu F, Ma L, Zhang T, Wang Y, Huang S, Zhao W, Chen X
Molecular neurobiology 2023 May;60(5):2922-2936
Molecular neurobiology 2023 May;60(5):2922-2936
Warming Menstruation and Analgesic Soup Inhibits PD-1/PD-L1 Pathway in Rats with Endometriosis.
Feng D, Wang X, Huang Y, Chen X, Xu R, Qu Z, Chou D
Alternative therapies in health and medicine 2023 May;29(4):152-157
Alternative therapies in health and medicine 2023 May;29(4):152-157
ERK and USP5 govern PD-1 homeostasis via deubiquitination to modulate tumor immunotherapy.
Xiao X, Shi J, He C, Bu X, Sun Y, Gao M, Xiang B, Xiong W, Dai P, Mao Q, Xing X, Yao Y, Yu H, Xu G, Li S, Ren Y, Chen B, Jiang C, Meng G, Lee YR, Wei W, Freeman GJ, Xie C, Zhang J
Nature communications 2023 May 19;14(1):2859
Nature communications 2023 May 19;14(1):2859
Targeting HMGA1 contributes to immunotherapy in aggressive breast cancer while suppressing EMT.
Chang X, Liu J, Yang Q, Gao Y, Ding X, Zhao J, Li Y, Liu Z, Li Z, Wu Y, Zuo D
Biochemical pharmacology 2023 Jun;212:115582
Biochemical pharmacology 2023 Jun;212:115582
Interaction of immune checkpoint PD-1 and chemokine receptor 4 (CXCR4) promotes a malignant phenotype in pancreatic cancer cells.
Harper MM, Lin M, Cavnar MJ, Pandalai PK, Patel RA, Gao M, Kim J
PloS one 2022;17(7):e0270832
PloS one 2022;17(7):e0270832
Transcriptomic analysis of graft liver provides insight into the immune response of rat liver transplantation.
Cao W, Lu J, Li S, Song F, Xu J
Frontiers in immunology 2022;13:947437
Frontiers in immunology 2022;13:947437
Identification and experimental validation of a tumor-infiltrating lymphocytes-related long noncoding RNA signature for prognosis of clear cell renal cell carcinoma.
Deng Y, Guo K, Tang Z, Feng Y, Cai S, Ye J, Xi Y, Li J, Liu R, Cai C, Tan Z, Zhang Y, Han Z, Zeng G, Zhong W
Frontiers in immunology 2022;13:1046790
Frontiers in immunology 2022;13:1046790
Anemoside B4 ameliorates experimental autoimmune encephalomyelitis in mice by modulating inflammatory responses and the gut microbiota.
Zou M, Chen FJ, Deng LR, Han Q, Huang CY, Shen SS, Tomlinson B, Li YH
European journal of pharmacology 2022 Sep 15;931:175185
European journal of pharmacology 2022 Sep 15;931:175185
Anemoside B4 protects against chronic relapsing colitis in mice by modulating inflammatory response, colonic transcriptome and the gut microbiota.
Han Q, Deng LR, Zou M, Tang HZ, Huang CY, Chen FJ, Tomlinson B, Li YH
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Nov;106:154416
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Nov;106:154416
PD-1 engineered cytomembrane cloaked molybdenum nitride for synergistic photothermal and enhanced immunotherapy of breast cancer.
Zhu L, Liu JL, Yang JT, Wu DW, Xu N, Huo KF, Wang HB
Journal of materials chemistry. B 2022 Nov 16;10(44):9249-9257
Journal of materials chemistry. B 2022 Nov 16;10(44):9249-9257
Overexpression of Programmed Cell Death 1 Prevents Doxorubicin-Induced Apoptosis Through Autophagy Induction in H9c2 Cardiomyocytes.
Kanno SI, Hara A
Cardiovascular toxicology 2022 May;22(5):462-476
Cardiovascular toxicology 2022 May;22(5):462-476
Glutamine deprivation impairs function of infiltrating CD8(+) T cells in hepatocellular carcinoma by inducing mitochondrial damage and apoptosis.
Wang W, Guo MN, Li N, Pang DQ, Wu JH
World journal of gastrointestinal oncology 2022 Jun 15;14(6):1124-1140
World journal of gastrointestinal oncology 2022 Jun 15;14(6):1124-1140
The immunomodulatory effect of microglia on ECM neuroinflammation via the PD-1/PD-L1 pathway.
Shen Y, Li Y, Zhu Q, Wang J, Huang Y, Liang J, Wu X, Zhao Y
CNS neuroscience & therapeutics 2022 Jan;28(1):46-63
CNS neuroscience & therapeutics 2022 Jan;28(1):46-63
CMTM6: increased circulating level and up-regulated expression in labial salivary glands in patients with primary Sjogren's syndrome.
Qian S, Xu J, Zhao S, Yang P, Yang C
Clinical and experimental immunology 2022 Jan 28;207(1):65-71
Clinical and experimental immunology 2022 Jan 28;207(1):65-71
Overcoming PD-1 Inhibitor Resistance with a Monoclonal Antibody to Secreted Frizzled-Related Protein 2 in Metastatic Osteosarcoma.
Nasarre P, Garcia DI, Siegel JB, Bonilla IV, Mukherjee R, Hilliard E, Chakraborty P, Nasarre C, Yustein JT, Lang M, Jaffa AA, Mehrotra S, Klauber-DeMore N
Cancers 2021 May 30;13(11)
Cancers 2021 May 30;13(11)
The mRNA expression of Il6 and Pdcd1 are predictive and protective factors for doxorubicin‑induced cardiotoxicity.
Kanno SI, Hara A
Molecular medicine reports 2021 Feb;23(2)
Molecular medicine reports 2021 Feb;23(2)
Targeted elimination of myeloid-derived suppressor cells via regulation of the STAT pathway alleviates tumor immunosuppression in neuroblastoma.
Xu W, Li S, Li M, Yang X, Xie S, Lin L, Li G, Zhou H
Immunology letters 2021 Dec;240:31-40
Immunology letters 2021 Dec;240:31-40
Elevated lymphocyte specific protein 1 expression is involved in the regulation of leukocyte migration and immunosuppressive microenvironment in glioblastoma.
Cao JY, Guo Q, Guan GF, Zhu C, Zou CY, Zhang LY, Cheng W, Wang GL, Cheng P, Wu AH, Li GY
Aging 2020 Jan 29;12(2):1656-1684
Aging 2020 Jan 29;12(2):1656-1684
Berberine Maintains the Neutrophil N1 Phenotype to Reverse Cancer Cell Resistance to Doxorubicin.
Zhang S, Zhou L, Zhang M, Wang Y, Wang M, Du J, Gu W, Kui F, Li J, Geng S, Du G
Frontiers in pharmacology 2019;10:1658
Frontiers in pharmacology 2019;10:1658
Survival analysis with regard to PD-L1 and CD155 expression in human small cell lung cancer and a comparison with associated receptors.
Xu Y, Cui G, Jiang Z, Li N, Zhang X
Oncology letters 2019 Mar;17(3):2960-2968
Oncology letters 2019 Mar;17(3):2960-2968
m(6)A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade.
Yang S, Wei J, Cui YH, Park G, Shah P, Deng Y, Aplin AE, Lu Z, Hwang S, He C, He YY
Nature communications 2019 Jun 25;10(1):2782
Nature communications 2019 Jun 25;10(1):2782
Programmed cell death ligand 1 (PD-L1) expression is not a predominant feature in Ewing sarcomas.
Spurny C, Kailayangiri S, Jamitzky S, Altvater B, Wardelmann E, Dirksen U, Hardes J, Hartmann W, Rossig C
Pediatric blood & cancer 2018 Jan;65(1)
Pediatric blood & cancer 2018 Jan;65(1)
Impact of mismatch-repair deficiency on the colorectal cancer immune microenvironment.
Zhang Y, Sun Z, Mao X, Wu H, Luo F, Wu X, Zhou L, Qin J, Zhao L, Bai C
Oncotarget 2017 Oct 17;8(49):85526-85536
Oncotarget 2017 Oct 17;8(49):85526-85536
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