66220-1-Ig

antibody from Proteintech Group

Targeting: PDCD1 CD279, hSLE1, PD-1, PD1, SLEB2

Provider product page for 66220-1-Ig

Western blot

ELISA

Immunocytochemistry

Immunohistochemistry

Flow cytometry

Antibody data

Antibody Data
Antigen structure
References [41]
Comments [0]
Validations [0]

Submit

Product number: 66220-1-Ig - Provider product page
Provider: Proteintech Group
Product name: PD-1/CD279 antibody
Antibody type: Monoclonal
Description: PD-1/CD279 antibody (Cat. #66220-1-Ig) is a mouse monoclonal antibody that shows reactivity with human, rat, mouse and has been validated for the following applications: FC, IF, IHC, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Mouse
Conjugate: Unconjugated
Isotype: IgG
Antibody clone number: 4H4D1
Vial size: 20ul, 150ul

PDCD1 protein structure - 66220-1-Ig shown in red.

Submitted references Radix Bupleuri-Radix Paeoniae Alba Inhibits the Development of Hepatocellular Carcinoma through Activation of the PTEN/PD-L1 Axis within the Immune Microenvironment.

Zhang F, Zhou K, Yuan W, Sun K
Nutrition and cancer 2024;76(1):63-79

Vimentin, inversely correlating with infiltration of CD8 + T lymphocytes, promotes nuclear translocation of PD-L1 in esophageal squamous cell carcinoma.

Liang Y, He S, Liu Q, Liu T, Tan Y, Peng T, Huang C, Lu X, Zheng S
Biochimica et biophysica acta. Molecular cell research 2024 Oct;1871(7):119781

PD-1/PD-L1 axis is involved in the interaction between microglial polarization and glioma.

Wang XP, Guo W, Chen YF, Hong C, Ji J, Zhang XY, Dong YF, Sun XL
International immunopharmacology 2024 May 30;133:112074

EGCG suppresses PD-1 expression of T cells via inhibiting NF-κB phosphorylation and nuclear translocation.

Li ZD, Liu F, Zeng Y, Liu Y, Luo W, Yuan F, Li S, Li Q, Chen J, Fujita M, Zhang G, Li Y
International immunopharmacology 2024 May 30;133:112069

STING activation reprograms the microenvironment to sensitize NF1-related malignant peripheral nerve sheath tumors for immunotherapy.

Somatilaka BN, Madana L, Sadek A, Chen Z, Chandrasekaran S, McKay RM, Le LQ
The Journal of clinical investigation 2024 Mar 19;134(10)

Prognostic significance and immunological role of HPRT1 in human cancers.

Lu Y, Chen R, Zhang H, Sun X, Li X, Yang M, Zhang X
Biomolecules & biomedicine 2024 Mar 11;24(2):262-291

Metabolic landscape of head and neck squamous cell carcinoma informs a novel kynurenine/Siglec-15 axis in immune escape.

Zhang XY, Shi JB, Jin SF, Wang RJ, Li MY, Zhang ZY, Yang X, Ma HL
Cancer communications (London, England) 2024 Jun;44(6):670-694

Pan-Cancer Single-Cell and Spatial-Resolved Profiling Reveals the Immunosuppressive Role of APOE+ Macrophages in Immune Checkpoint Inhibitor Therapy.

Liu C, Xie J, Lin B, Tian W, Wu Y, Xin S, Hong L, Li X, Liu L, Jin Y, Tang H, Deng X, Zou Y, Zheng S, Fang W, Cheng J, Dai X, Bao X, Zhao P
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Jun;11(23):e2401061

The single cell immunogenomic landscape after neoadjuvant immunotherapy combined chemotherapy in esophageal squamous cell carcinoma.

Wang Z, Zhao Y, Wo Y, Peng Y, Hu W, Wu Z, Liu P, Shang Y, Liu C, Chen X, Huang K, Chen Y, Hong H, Li F, Sun Y
Cancer letters 2024 Jul 1;593:216951

An anti-PD-1 antisense oligonucleotide promotes the expression of soluble PD-1 by blocking the interaction between SRSF3 and an exonic splicing enhancer of PD-1 exon 3.

Wang X, Yan L, Guo J, Jia R
International immunopharmacology 2024 Jan 5;126:111280

Extra villous trophoblast-derived PDL1 can ameliorate macrophage inflammation and promote immune adaptation associated with preeclampsia.

Cui Y, Wu S, Liu K, Zhao H, Ma B, Gong L, Zhou Q, Li X
Journal of reproductive immunology 2024 Feb;161:104186

The deubiquitinase USP2a promotes tumor immunosuppression by stabilizing immune checkpoint B7-H4 in lung adenocarcinoma harboring EGFR-activating mutants.

Lu Y, Sun Y, Zhang J, Kong M, Zhao Z, Sun B, Wang Y, Jiang Y, Chen S, Wang C, Tong Y, Wen L, Huang M, Wu F, Zhang L
Cancer letters 2024 Aug 1;596:217020

Anti-PD-1 treatment protects against seizure by suppressing sodium channel function.

Yang Y, Chen Z, Zhou J, Jiang S, Wang G, Wan L, Yu J, Jiang M, Wang Y, Hu J, Liu X, Wang Y
CNS neuroscience & therapeutics 2024 Apr;30(4):e14504

C. tropicalis promotes CRC by down-regulating tumor cell-intrinsic PD-1 receptor via autophagy.

Qu J, Chen Q, Bing Z, Shen S, Hou Y, Lv M, Wang T
Journal of Cancer 2023;14(10):1794-1808

PD1 is transcriptionally regulated by LEF1 in mature T cells.

Zhao P, Sun L, Zhao C, Malik S
Immunobiology 2023 Sep;228(5):152708

Effects of Nanosecond Pulsed Electric Field on Immune Checkpoint Receptors in Melanoma Cells.

Sauer N, Szlasa W, Szewczyk A, Novickij V, Saczko J, Baczyńska D, Daczewska M, Kulbacka J
Pharmaceuticals (Basel, Switzerland) 2023 Sep 27;16(10)

Extracellular nicotinamide phosphoribosyltransferase (eNAMPT) neutralization counteracts T cell immune evasion in breast cancer.

Travelli C, Colombo G, Aliotta M, Fagiani F, Fava N, De Sanctis R, Grolla AA, Garcia JGN, Clemente N, Portararo P, Costanza M, Condorelli F, Colombo MP, Sangaletti S, Genazzani AA
Journal for immunotherapy of cancer 2023 Oct;11(10)

Attenuated Salmonella-delivered PD-1 siRNA enhances the antitumor effects of EZH2 inhibitors in colorectal cancer.

Lv M, Guo S, Zhang X, Zou Y, Chen Q, Zang C, Huang S, Hu Y, Wang Y, Wang Q, Zhong J
International immunopharmacology 2023 Nov;124(Pt A):110918

Electroacupuncture Alleviates CFA-Induced Inflammatory Pain via PD-L1/PD-1-SHP-1 Pathway.

Deng D, Xu F, Ma L, Zhang T, Wang Y, Huang S, Zhao W, Chen X
Molecular neurobiology 2023 May;60(5):2922-2936

Warming Menstruation and Analgesic Soup Inhibits PD-1/PD-L1 Pathway in Rats with Endometriosis.

Feng D, Wang X, Huang Y, Chen X, Xu R, Qu Z, Chou D
Alternative therapies in health and medicine 2023 May;29(4):152-157

ERK and USP5 govern PD-1 homeostasis via deubiquitination to modulate tumor immunotherapy.

Xiao X, Shi J, He C, Bu X, Sun Y, Gao M, Xiang B, Xiong W, Dai P, Mao Q, Xing X, Yao Y, Yu H, Xu G, Li S, Ren Y, Chen B, Jiang C, Meng G, Lee YR, Wei W, Freeman GJ, Xie C, Zhang J
Nature communications 2023 May 19;14(1):2859

Targeting HMGA1 contributes to immunotherapy in aggressive breast cancer while suppressing EMT.

Chang X, Liu J, Yang Q, Gao Y, Ding X, Zhao J, Li Y, Liu Z, Li Z, Wu Y, Zuo D
Biochemical pharmacology 2023 Jun;212:115582

Interaction of immune checkpoint PD-1 and chemokine receptor 4 (CXCR4) promotes a malignant phenotype in pancreatic cancer cells.

Harper MM, Lin M, Cavnar MJ, Pandalai PK, Patel RA, Gao M, Kim J
PloS one 2022;17(7):e0270832

Transcriptomic analysis of graft liver provides insight into the immune response of rat liver transplantation.

Cao W, Lu J, Li S, Song F, Xu J
Frontiers in immunology 2022;13:947437

Identification and experimental validation of a tumor-infiltrating lymphocytes-related long noncoding RNA signature for prognosis of clear cell renal cell carcinoma.

Deng Y, Guo K, Tang Z, Feng Y, Cai S, Ye J, Xi Y, Li J, Liu R, Cai C, Tan Z, Zhang Y, Han Z, Zeng G, Zhong W
Frontiers in immunology 2022;13:1046790

Anemoside B4 ameliorates experimental autoimmune encephalomyelitis in mice by modulating inflammatory responses and the gut microbiota.

Zou M, Chen FJ, Deng LR, Han Q, Huang CY, Shen SS, Tomlinson B, Li YH
European journal of pharmacology 2022 Sep 15;931:175185

Anemoside B4 protects against chronic relapsing colitis in mice by modulating inflammatory response, colonic transcriptome and the gut microbiota.

Han Q, Deng LR, Zou M, Tang HZ, Huang CY, Chen FJ, Tomlinson B, Li YH
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Nov;106:154416

PD-1 engineered cytomembrane cloaked molybdenum nitride for synergistic photothermal and enhanced immunotherapy of breast cancer.

Zhu L, Liu JL, Yang JT, Wu DW, Xu N, Huo KF, Wang HB
Journal of materials chemistry. B 2022 Nov 16;10(44):9249-9257

Overexpression of Programmed Cell Death 1 Prevents Doxorubicin-Induced Apoptosis Through Autophagy Induction in H9c2 Cardiomyocytes.

Kanno SI, Hara A
Cardiovascular toxicology 2022 May;22(5):462-476

Glutamine deprivation impairs function of infiltrating CD8(+) T cells in hepatocellular carcinoma by inducing mitochondrial damage and apoptosis.

Wang W, Guo MN, Li N, Pang DQ, Wu JH
World journal of gastrointestinal oncology 2022 Jun 15;14(6):1124-1140

The immunomodulatory effect of microglia on ECM neuroinflammation via the PD-1/PD-L1 pathway.

Shen Y, Li Y, Zhu Q, Wang J, Huang Y, Liang J, Wu X, Zhao Y
CNS neuroscience & therapeutics 2022 Jan;28(1):46-63

CMTM6: increased circulating level and up-regulated expression in labial salivary glands in patients with primary Sjogren's syndrome.

Qian S, Xu J, Zhao S, Yang P, Yang C
Clinical and experimental immunology 2022 Jan 28;207(1):65-71

Overcoming PD-1 Inhibitor Resistance with a Monoclonal Antibody to Secreted Frizzled-Related Protein 2 in Metastatic Osteosarcoma.

Nasarre P, Garcia DI, Siegel JB, Bonilla IV, Mukherjee R, Hilliard E, Chakraborty P, Nasarre C, Yustein JT, Lang M, Jaffa AA, Mehrotra S, Klauber-DeMore N
Cancers 2021 May 30;13(11)

The mRNA expression of Il6 and Pdcd1 are predictive and protective factors for doxorubicin‑induced cardiotoxicity.

Kanno SI, Hara A
Molecular medicine reports 2021 Feb;23(2)

Targeted elimination of myeloid-derived suppressor cells via regulation of the STAT pathway alleviates tumor immunosuppression in neuroblastoma.

Xu W, Li S, Li M, Yang X, Xie S, Lin L, Li G, Zhou H
Immunology letters 2021 Dec;240:31-40

Elevated lymphocyte specific protein 1 expression is involved in the regulation of leukocyte migration and immunosuppressive microenvironment in glioblastoma.

Cao JY, Guo Q, Guan GF, Zhu C, Zou CY, Zhang LY, Cheng W, Wang GL, Cheng P, Wu AH, Li GY
Aging 2020 Jan 29;12(2):1656-1684

Berberine Maintains the Neutrophil N1 Phenotype to Reverse Cancer Cell Resistance to Doxorubicin.

Zhang S, Zhou L, Zhang M, Wang Y, Wang M, Du J, Gu W, Kui F, Li J, Geng S, Du G
Frontiers in pharmacology 2019;10:1658

Survival analysis with regard to PD-L1 and CD155 expression in human small cell lung cancer and a comparison with associated receptors.

Xu Y, Cui G, Jiang Z, Li N, Zhang X
Oncology letters 2019 Mar;17(3):2960-2968

m(6)A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade.

Yang S, Wei J, Cui YH, Park G, Shah P, Deng Y, Aplin AE, Lu Z, Hwang S, He C, He YY
Nature communications 2019 Jun 25;10(1):2782

Programmed cell death ligand 1 (PD-L1) expression is not a predominant feature in Ewing sarcomas.

Spurny C, Kailayangiri S, Jamitzky S, Altvater B, Wardelmann E, Dirksen U, Hardes J, Hartmann W, Rossig C
Pediatric blood & cancer 2018 Jan;65(1)

Impact of mismatch-repair deficiency on the colorectal cancer immune microenvironment.

Zhang Y, Sun Z, Mao X, Wu H, Luo F, Wu X, Zhou L, Qin J, Zhao L, Bai C
Oncotarget 2017 Oct 17;8(49):85526-85536

No comments: Submit comment

No validations: Submit validation data