Antibody data
- Antibody Data
- Antigen structure
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- Product number
- 329943 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#329943, RRID:AB_2565904
- Product name
- GoInVivo™ Purified anti-human CD279 (PD-1)
- Antibody type
- Monoclonal
- Antigen
- Other
- Description
- Programmed cell death 1 (PD-1), also known as CD279, is a 55 kD member of the immunoglobulin superfamily. CD279 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) in the cytoplasmic region and plays a key role in peripheral tolerance and autoimmune disease. CD279 is expressed predominantly on activated T cells, B cells, and myeloid cells. PD-L1 (B7-H1) and PD-L2 (B7-DC) are ligands of CD279 (PD-1) and are members of the B7 gene family. Evidence suggests overlapping functions for these two PD-1 ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. Interaction of CD279 ligands results in inhibition of T cell proliferation and cytokine secretion.
- Reactivity
- Human
- Host
- Mouse
- Antibody clone number
- EH12.2H7
- Vial size
- 100 mg
- Storage
- 2°C-8°C
- Handling
- Ambient RT
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