GTX20256

Kammerer-Jacquet SF, Crouzet L, Brunot A, Dagher J, Pladys A, Edeline J, Laguerre B, Peyronnet B, Mathieu R, Verhoest G, Patard JJ, Lespagnol A, Mosser J, Denis M, Messai Y, Gad-Lapiteau S, Chouaib S, Belaud-Rotureau MA, Bensalah K, Rioux-Leclercq N
International journal of cancer 2017 Jan 1;140(1):142-148

Crucial Contributions by T Lymphocytes (Effector, Regulatory, and Checkpoint Inhibitor) and Cytokines (TH1, TH2, and TH17) to a Pathological Complete Response Induced by Neoadjuvant Chemotherapy in Women with Breast Cancer.

Kaewkangsadan V, Verma C, Eremin JM, Cowley G, Ilyas M, Eremin O
Journal of immunology research 2016;2016:4757405

Assessing PDL-1 and PD-1 in Non-Small Cell Lung Cancer: A Novel Immunoscore Approach.

Paulsen EE, Kilvaer TK, Khanehkenari MR, Al-Saad S, Hald SM, Andersen S, Richardsen E, Ness N, Busund LT, Bremnes RM, Donnem T
Clinical lung cancer 2016 Oct 5;

T cell Bim levels reflect responses to anti-PD-1 cancer therapy.

Dronca RS, Liu X, Harrington SM, Chen L, Cao S, Kottschade LA, McWilliams RR, Block MS, Nevala WK, Thompson MA, Mansfield AS, Park SS, Markovic SN, Dong H
JCI insight 2016 May 5;1(6)

Tumor-Infiltrating T Cells and the PD-1 Checkpoint Pathway in Advanced Differentiated and Anaplastic Thyroid Cancer.

Bastman JJ, Serracino HS, Zhu Y, Koenig MR, Mateescu V, Sams SB, Davies KD, Raeburn CD, McIntyre RC Jr, Haugen BR, French JD
The Journal of clinical endocrinology and metabolism 2016 Jul;101(7):2863-73

Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity.

Li CW, Lim SO, Xia W, Lee HH, Chan LC, Kuo CW, Khoo KH, Chang SS, Cha JH, Kim T, Hsu JL, Wu Y, Hsu JM, Yamaguchi H, Ding Q, Wang Y, Yao J, Lee CC, Wu HJ, Sahin AA, Allison JP, Yu D, Hortobagyi GN, Hung MC
Nature communications 2016 Aug 30;7:12632

Lichenoid dermatitis in three patients with metastatic melanoma treated with anti-PD-1 therapy.

Joseph RW, Cappel M, Goedjen B, Gordon M, Kirsch B, Gilstrap C, Bagaria S, Jambusaria-Pahlajani A
Cancer immunology research 2015 Jan;3(1):18-22

Differential induction of PD-1/PD-L1 in Neuroimmune cells by drug of abuse.

Mishra V, Schuetz H, Haorah J
International journal of physiology, pathophysiology and pharmacology 2015 Aug 15;7(2):87-97

The histopathology of labial salivary glands in primary Sjögren's syndrome: focusing on follicular helper T cells in the inflammatory infiltrates.

Szabo K, Papp G, Dezso B, Zeher M
Mediators of inflammation 2014;2014:631787

Pattern of CD14+ follicular dendritic cells and PD1+ T cells independently predicts time to transformation in follicular lymphoma.

Smeltzer JP, Jones JM, Ziesmer SC, Grote DM, Xiu B, Ristow KM, Yang ZZ, Nowakowski GS, Feldman AL, Cerhan JR, Novak AJ, Ansell SM
Clinical cancer research : an official journal of the American Association for Cancer Research 2014 Jun 1;20(11):2862-72

Utility of CD279/PD-1 immunohistochemistry in the evaluation of benign and neoplastic T-cell-rich bone marrow infiltrates.

Cogbill CH, Swerdlow SH, Gibson SE
American journal of clinical pathology 2014 Jul;142(1):88-98

Defective B-cell memory in patients with Down syndrome.

Verstegen RH, Driessen GJ, Bartol SJ, van Noesel CJ, Boon L, van der Burg M, van Dongen JJ, de Vries E, van Zelm MC
The Journal of allergy and clinical immunology 2014 Dec;134(6):1346-1353.e9

Presence of antigen-experienced T cells with low grade of differentiation and proliferative potential in chronic Chagas disease myocarditis.

Argüello RJ, Vigliano C, Cabeza-Meckert P, Viotti R, Garelli F, Favaloro LE, Favaloro RR, Laguens R, Laucella SA
PLoS neglected tropical diseases 2014 Aug 21;8(8):e2989

Cell distance mapping identifies functional T follicular helper cells in inflamed human renal tissue.

Liarski VM, Kaverina N, Chang A, Brandt D, Yanez D, Talasnik L, Carlesso G, Herbst R, Utset TO, Labno C, Peng Y, Jiang Y, Giger ML, Clark MR
Science translational medicine 2014 Apr 2;6(230):230ra46

Antagonist antibodies to PD-1 and B7-H1 (PD-L1) in the treatment of advanced human cancer.

Sznol M, Chen L
Clinical cancer research : an official journal of the American Association for Cancer Research 2013 Mar 1;19(5):1021-34

Tumor-infiltrating PD1-Positive Lymphocytes and FoxP3-Positive Regulatory T Cells Predict Distant Metastatic Relapse and Survival of Clear Cell Renal Cell Carcinoma.

Kang MJ, Kim KM, Bae JS, Park HS, Lee H, Chung MJ, Moon WS, Lee DG, Jang KY
Translational oncology 2013 Jun;6(3):282-9

Angioimmunoblastic T-cell lymphoma mice model.

Sato F, Ishida T, Ito A, Mori F, Masaki A, Takino H, Narita T, Ri M, Kusumoto S, Suzuki S, Komatsu H, Niimi A, Ueda R, Inagaki H, Iida S
Leukemia research 2013 Jan;37(1):21-7

Tumor infiltrating PD1-positive lymphocytes and the expression of PD-L1 predict poor prognosis of soft tissue sarcomas.

Kim JR, Moon YJ, Kwon KS, Bae JS, Wagle S, Kim KM, Park HS, Lee H, Moon WS, Chung MJ, Kang MJ, Jang KY
PloS one 2013 Dec 11;8(12):e82870

Programmed death-1+ T cells and regulatory T cells are enriched in tumor-involved lymph nodes and associated with aggressive features in papillary thyroid cancer.

French JD, Kotnis GR, Said S, Raeburn CD, McIntyre RC Jr, Klopper JP, Haugen BR
The Journal of clinical endocrinology and metabolism 2012 Jun;97(6):E934-43

Clinicopathologic analysis of peripheral T-cell lymphoma, follicular variant, and comparison with angioimmunoblastic T-cell lymphoma: Bcl-6 expression might affect progression between these disorders.

Miyoshi H, Sato K, Niino D, Arakawa F, Kimura Y, Kiyasu J, Takeuchi M, Yoshida M, Okada Y, Nakamura Y, Sugita Y, Ohshima K
American journal of clinical pathology 2012 Jun;137(6):879-89

Regulatory T-cell depletion in angioimmunoblastic T-cell lymphoma.

Bruneau J, Canioni D, Renand A, Marafioti T, Paterson JC, Martin-Garcia N, Gaulard P, Delfau MH, Hermine O, Macintyre E, Brousse N, Asnafi V
The American journal of pathology 2010 Aug;177(2):570-4

Diffuse large B-cell lymphoma with a high number of epithelioid histiocytes (lymphoepithelioid B-cell lymphoma): a study of Osaka Lymphoma Study Group.

Wada N, Ikeda J, Kohara M, Ogawa H, Hino M, Fukuhara S, Kanamaru A, Sugiyama H, Kanakura Y, Morii E, Aozasa K
Virchows Archiv : an international journal of pathology 2009 Sep;455(3):285-93

Expression of two markers of germinal center T cells (SAP and PD-1) in angioimmunoblastic T-cell lymphoma.

Roncador G, García Verdes-Montenegro JF, Tedoldi S, Paterson JC, Klapper W, Ballabio E, Maestre L, Pileri S, Hansmann ML, Piris MA, Mason DY, Marafioti T
Haematologica 2007 Aug;92(8):1059-66

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Main image
Experimental details: IHC-P analysis of human tonsil tissue using GTX20256 PD1 antibody [NAT105].