BS2298

antibody from Bioworld Technology, Inc

Targeting: DMPK DM, DM1, DM1PK, DMK, MDPK, MT-PK

Western blot (Data presented on provider website)

Antibody Data

Product number

BS2298

Provider

Bioworld Technology, Inc

Proper citation

Bioworld Technology Cat#BS2298, RRID:AB_1662156

Product name

DMPK (R30) polyclonal antibody

Antibody type

Polyclonal

Antigen

Synthetic peptide, corresponding to the N-terminus of Human DMPK.

Description

Myotonic dystrophy protein kinase (DMPK) is a ulti-domain protein kinase found in muscle that is activated in response to G protein second messengers and proteolysis. DMPK is implicated in myotonic muscular dystrophy (DM), an autosomal dominant-inherited disorder that predominately affects skeletal and cardiac muscle and causes defects in cardiac conduction. DM arises through expansion of CTG repeats in the 3£ª-UTR of the DMPK gene. Mutant DMPK transcripts with an extended region of CUG repeats are retained in the nucleus. These transcripts also influence the expression of the DM locus-associated homeodomain protein (DMAHP)/SIX5, to mediate in part the DM phenotype. Other substrates for DMPK include myogenin, Ltype calcium channels, and Phospholemman (PLM).

Reactivity

Human

Host

Rabbit

Isotype

IgG

Vial size

100ul

Concentration

1 mg/ml

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.