ABIN500345

antibody from antibodies-online

Targeting: NCSTN APH2, KIAA0253

Western blot (Supportive data in Antibodypedia)

ELISA (Recommended by provider)

Immunohistochemistry (Supportive data in Antibodypedia)

Antibody Data

Product number

ABIN500345

Provider

antibodies-online

Product name

anti-Nicastrin (NCSTN) antibody

Antibody type

Polyclonal

Antigen

Nicastrin antibody was raised against a 18 amino acid peptide from near the center ofhuman Nicastrin.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Isotype

IgG

Vial size

0.1 mg

Storage

Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer. Avoid repeatedfreezing and thawing. Shelf life: one year from despatch.

References

Submitted references

Loss of nicastrin elicits an apoptotic phenotype in mouse embryos.

Nguyen V, Hawkins C, Bergeron C, Supala A, Huang J, Westaway D, St George-Hyslop P, Rozmahel R
Brain research 2006 May 1;1086(1):76-84

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Functional reconstitution of gamma-secretase through coordinated expression of presenilin, nicastrin, Aph-1, and Pen-2.

Periz G, Fortini ME
Journal of neuroscience research 2004 Aug 1;77(3):309-22

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Intramembrane-cleaving proteases: controlled liberation of proteins and bioactive peptides.

Weihofen A, Martoglio B
Trends in cell biology 2003 Feb;13(2):71-8

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The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease.

Selkoe DJ
Trends in cell biology 1998 Nov;8(11):447-53

Western blot

Supportive validation

Submitted by

antibodies-online (provider)

Main image

Experimental details

Western blot analysis of Nicastrin in human brain tissue lysate with AP30594PU-N at (A) 0.5 and (B) 1?g/ml.

Immunohistochemistry

Supportive validation

Submitted by

antibodies-online (provider)

Main image

Experimental details

Immunohistochemistry of Nicastrin in human brain tissue with AP30594PU-N at 2.5 ?g/ml.