Antibody data
- Antibody Data
- Antigen structure
- References [4]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
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Validation data
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- Product number
- ABIN500345 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-Nicastrin (NCSTN) antibody
- Antibody type
- Polyclonal
- Antigen
- Nicastrin antibody was raised against a 18 amino acid peptide from near the center ofhuman Nicastrin.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 0.1 mg
- Storage
- Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer. Avoid repeatedfreezing and thawing. Shelf life: one year from despatch.
Submitted references Loss of nicastrin elicits an apoptotic phenotype in mouse embryos.
Functional reconstitution of gamma-secretase through coordinated expression of presenilin, nicastrin, Aph-1, and Pen-2.
Intramembrane-cleaving proteases: controlled liberation of proteins and bioactive peptides.
The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease.
Nguyen V, Hawkins C, Bergeron C, Supala A, Huang J, Westaway D, St George-Hyslop P, Rozmahel R
Brain research 2006 May 1;1086(1):76-84
Brain research 2006 May 1;1086(1):76-84
Functional reconstitution of gamma-secretase through coordinated expression of presenilin, nicastrin, Aph-1, and Pen-2.
Periz G, Fortini ME
Journal of neuroscience research 2004 Aug 1;77(3):309-22
Journal of neuroscience research 2004 Aug 1;77(3):309-22
Intramembrane-cleaving proteases: controlled liberation of proteins and bioactive peptides.
Weihofen A, Martoglio B
Trends in cell biology 2003 Feb;13(2):71-8
Trends in cell biology 2003 Feb;13(2):71-8
The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease.
Selkoe DJ
Trends in cell biology 1998 Nov;8(11):447-53
Trends in cell biology 1998 Nov;8(11):447-53
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Supportive validation
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- Western blot analysis of Nicastrin in human brain tissue lysate with AP30594PU-N at (A) 0.5 and (B) 1?g/ml.
Supportive validation
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- Immunohistochemistry of Nicastrin in human brain tissue with AP30594PU-N at 2.5 ?g/ml.