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Protein structure
NCSTN
NicastrinAPH2, KIAA0253
This gene encodes a type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease; however, the nature of the encoded protein's role in Alzheimer's disease is not known for certain. Mutations in this gene are associated with familial acne inversa. A pseudogene of this gene is present on chromosome 21. Alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Feb 2014]
Top validated antibodies |
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| Proteintech Group |  14071-1-AP |
6 references | Polyclonal |
WB
EL
ICC
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| antibodies-online | ABIN500345 |
4 references | Polyclonal |
WB
EL
IHC
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| GeneTex | GTX31751 |
Polyclonal |
WB
EL
ICC
IHC
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| Invitrogen Antibodies | MA5-29438 |
Monoclonal |
WB
ICC
IP
OA
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| LSBio | LS-C806059 |
Polyclonal |
WB
EL
ICC
IHC
|
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