NCSTN

gene product
APH2, KIAA0253
This gene encodes a type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease; however, the nature of the encoded protein's role in Alzheimer's disease is not known for certain. Mutations in this gene are associated with familial acne inversa. A pseudogene of this gene is present on chromosome 21. Alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Feb 2014]
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Novus Biologicals
26 antibodies
GeneTex
5 antibodies
antibodies-online
132 antibodies
Abnova Corporation
8 antibodies
LifeSpan BioSciences, Inc.
63 antibodies
OriGene
6 antibodies
Invitrogen Antibodies
4 antibodies
Rockland Immunochemicals, Inc.
2 antibodies
Biorbyt
31 antibodies
NovoPro Bioscience Inc.
13 antibodies
Acris Antibodies GmbH
15 antibodies
ProSci
3 antibodies
Abgent
5 antibodies
Cell Signaling Technology, Inc
4 antibodies
Affinity Biosciences
1 antibody
R&D Systems
4 antibodies
Enzo Life Sciences
1 antibody
Bioworld Technology, Inc
1 antibody
Bethyl Laboratories
1 antibody
Proteintech Group
1 antibody
RabMAbs
4 antibodies
Atlas Antibodies
2 antibodies
Creative Biolabs
31 antibodies
MyBioSource
7 antibodies
NSJ Bioreagents
1 antibody
St John's Laboratory
3 antibodies
Creative Diagnostics
6 antibodies
Sino Biological Inc.
5 antibodies
Abbiotec
2 antibodies
RayBiotech, Inc.
3 antibodies
Boster Biological Technology
1 antibody
United States Biological
39 antibodies
Sigma-Aldrich
3 antibodies
BioLegend
2 antibodies
BioLegend (formerly Covance Antibody Products)
2 antibodies
EMD Millipore
2 antibodies
GenWay
3 antibodies
Aviva Systems Biology
2 antibodies