334204

antibody from BioLegend

Targeting: TEK CD202b, TIE-2, TIE2, VMCM, VMCM1

Flow cytometry (Data presented on provider website)

Antibody Data

Product number

334204

Provider

BioLegend

Proper citation

BioLegend Cat#334204, RRID:AB_1186046

Product name

Biotin anti-human CD202b (Tie2/Tek)

Antibody type

Monoclonal

Antigen

Recombinant extracellular domain of human Tie2

Description

CD202b is a 145 kD type I transmembrane protein, also known as Tie2 or TEK. It is a member of the receptor tyrosine kinase (RTK) family of proteins and is expressed by endothelial cells and their progenitors, quiescent hematopoietic stem cells (HSCs), and a subpopulation of monocytes. Angiopoietin-1 (Ang-1) is an activator of CD202b to promote, maintain, and stabilize mature vessels and to maintain HSCs in quiescent state. Ang-2 is another ligand of CD202b, which is involved in postnatal angiogenesis and in antagonizing the effects of Ang-1. Tie2 binds to Ang-4 as well.

Reactivity

Human

Host

Mouse

Conjugate

Biotin

Isotype

IgG

Vial size

100 µg

Concentration

0.5 mg/ml

Storage

The antibody solution should be stored undiluted at 4°C. Do not freeze.