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TEK
TEK receptor tyrosine kinaseCD202b, TIE-2, TIE2, VMCM, VMCM1
This gene encodes a receptor that belongs to the protein tyrosine kinase Tie2 family. The encoded protein possesses a unique extracellular region that contains two immunoglobulin-like domains, three epidermal growth factor (EGF)-like domains and three fibronectin type III repeats. The ligand angiopoietin-1 binds to this receptor and mediates a signaling pathway that functions in embryonic vascular development. Mutations in this gene are associated with inherited venous malformations of the skin and mucous membranes. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2014]
Top validated antibodies |
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| ReliaTech GmbH |  101-M50 |
4 references | Monoclonal |
WB
EL
IHC
FC
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| Novus Biologicals | NBP1-18614 |
1 references | Monoclonal |
WB
EL
ICC
IHC
FC
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| R&D Systems | AF313 |
22 references | Polyclonal |
WB
IHC
BN
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| Proteintech Group | 19157-1-AP |
8 references | Polyclonal |
WB
EL
IP
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| Boster Biological Technology | A01274-2 |
Polyclonal |
WB
EL
ICC
IHC
FC
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