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Other assayAntibody data
- Antibody Data
- Antigen structure
- References [5]
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- Validations
- Other assay [1]
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- Product number
- PA1-1750 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- ADAMTS4 Polyclonal Antibody
- Antibody type
- Polyclonal
- Antigen
- Synthetic peptide
- Description
- PA1-1750 detects ADAMTS4 from porcine, bovine, and human samples. PA1-1750 is specific for ADAMTS4 and shows no cross-reactivity with other ADAMTS family members.
- Concentration
- 1 mg/mL
Submitted references Neutrophil extracellular traps mediate articular cartilage damage and enhance cartilage component immunogenicity in rheumatoid arthritis.
Progranulin derivative Atsttrin protects against early osteoarthritis in mouse and rat models.
Interleukin-1alpha treatment of meniscal explants stimulates the production and release of aggrecanase-generated, GAG-substituted aggrecan products and also the release of pre-formed, aggrecanase-generated G1 and m-calpain-generated G1-G2.
Activation of the proteolytic activity of ADAMTS4 (aggrecanase-1) by C-terminal truncation.
Versican V1 proteolysis in human aorta in vivo occurs at the Glu441-Ala442 bond, a site that is cleaved by recombinant ADAMTS-1 and ADAMTS-4.
Carmona-Rivera C, Carlucci PM, Goel RR, James E, Brooks SR, Rims C, Hoffmann V, Fox DA, Buckner JH, Kaplan MJ
JCI insight 2020 Jul 9;5(13)
JCI insight 2020 Jul 9;5(13)
Progranulin derivative Atsttrin protects against early osteoarthritis in mouse and rat models.
Wei JL, Fu W, Ding YJ, Hettinghouse A, Lendhey M, Schwarzkopf R, Kennedy OD, Liu CJ
Arthritis research & therapy 2017 Dec 19;19(1):280
Arthritis research & therapy 2017 Dec 19;19(1):280
Interleukin-1alpha treatment of meniscal explants stimulates the production and release of aggrecanase-generated, GAG-substituted aggrecan products and also the release of pre-formed, aggrecanase-generated G1 and m-calpain-generated G1-G2.
Lemke AK, Sandy JD, Voigt H, Dreier R, Lee JH, Grodzinsky AJ, Mentlein R, Fay J, Schünke M, Kurz B
Cell and tissue research 2010 Apr;340(1):179-88
Cell and tissue research 2010 Apr;340(1):179-88
Activation of the proteolytic activity of ADAMTS4 (aggrecanase-1) by C-terminal truncation.
Gao G, Westling J, Thompson VP, Howell TD, Gottschall PE, Sandy JD
The Journal of biological chemistry 2002 Mar 29;277(13):11034-41
The Journal of biological chemistry 2002 Mar 29;277(13):11034-41
Versican V1 proteolysis in human aorta in vivo occurs at the Glu441-Ala442 bond, a site that is cleaved by recombinant ADAMTS-1 and ADAMTS-4.
Sandy JD, Westling J, Kenagy RD, Iruela-Arispe ML, Verscharen C, Rodriguez-Mazaneque JC, Zimmermann DR, Lemire JM, Fischer JW, Wight TN, Clowes AW
The Journal of biological chemistry 2001 Apr 20;276(16):13372-8
The Journal of biological chemistry 2001 Apr 20;276(16):13372-8
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