Tissue expression
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Protein structure

ADAMTS4

ADAM metallopeptidase with thrombospondin type 1 motif 4
ADAMTS-2, ADMP-1, KIAA0688 
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of this family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The expression of this gene is upregulated in arthritic disease and this may contribute to disease progression through the degradation of aggrecan. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]
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608 antibodies from 36 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
Invitrogen Antibodies
27 antibodies
Proteintech Group
1 antibody
R&D Systems
3 antibodies
Cusabio Biotech Co., Ltd
4 antibodies
Novus Biologicals
6 antibodies
antibodies-online
171 antibodies
Biorbyt
43 antibodies
Boster Biological Technology
2 antibodies
St John's Laboratory
3 antibodies
Affinity Biosciences
1 antibody
Abnova Corporation
8 antibodies
OriGene
21 antibodies
Aviva Systems Biology
3 antibodies
Bioworld Technology, Inc
1 antibody
GeneTex
6 antibodies
NSJ Bioreagents
2 antibodies
NovoPro Bioscience Inc.
6 antibodies
Abbkine Scientific Co.Ltd.
1 antibody
Acris Antibodies GmbH
12 antibodies
MyBioSource
8 antibodies
Atlas Antibodies
2 antibodies
Abgent
6 antibodies
RabMAbs
1 antibody
Abbexa
8 antibodies
ProSci
3 antibodies
Abbiotec
1 antibody
United States Biological
45 antibodies
Creative Diagnostics
2 antibodies
RayBiotech, Inc.
7 antibodies
GenWay
3 antibodies
Leading Biology
3 antibodies
EMD Millipore
2 antibodies
MilliporeSigma / Merck KGaA
5 antibodies
Creative Biolabs
26 antibodies