Tissue expression
Cell line expression

ADAMTS4

gene product
ADAMTS-2, ADMP-1, KIAA0688 
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of this family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The expression of this gene is upregulated in arthritic disease and this may contribute to disease progression through the degradation of aggrecan. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]
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586 antibodies from 36 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
Invitrogen Antibodies
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antibodies-online
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GeneTex
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NSJ Bioreagents
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Abbkine Scientific Co.Ltd.
1 antibody
Acris Antibodies GmbH
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MyBioSource
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Atlas Antibodies
2 antibodies
Abgent
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RabMAbs
1 antibody
Abbexa
8 antibodies
St John's Laboratory
3 antibodies
ProSci
3 antibodies
Abbiotec
1 antibody
United States Biological
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Creative Diagnostics
2 antibodies
RayBiotech, Inc.
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GenWay
3 antibodies
Leading Biology
3 antibodies
EMD Millipore
2 antibodies
MilliporeSigma / Merck KGaA
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Creative Biolabs
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