abx000591

antibody from Abbexa

Targeting: ATF6 ATF6A

Western blot (Recommended by provider)

Antibody Data

Product number

abx000591

Provider

Abbexa

Product name

Cyclic AMP-Dependent Transcription Factor ATF-6 Alpha (ATF6) Antibody

Antibody type

Polyclonal

Description

ATF6 Antibody is a Rabbit Polyclonal antibody against ATF6. This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis.

Reactivity

Human, Mouse

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

100 µl

Concentration

1.67 mg/ml

Storage

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.