ATF6

gene product
ATF6A
This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis. [provided by RefSeq, Aug 2011]
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572 antibodies from 41 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
Novus Biologicals
77 antibodies
GeneTex
6 antibodies
Enzo Life Sciences
2 antibodies
antibodies-online
171 antibodies
Abnova Corporation
11 antibodies
R&D Systems
8 antibodies
NovoPro Bioscience Inc.
1 antibody
Proteintech Group
1 antibody
LifeSpan BioSciences, Inc.
100 antibodies
Aviva Systems Biology
3 antibodies
Biorbyt
35 antibodies
OriGene
14 antibodies
NSJ Bioreagents
5 antibodies
Abgent
6 antibodies
Invitrogen Antibodies
8 antibodies
Acris Antibodies GmbH
15 antibodies
Rockland Immunochemicals, Inc.
4 antibodies
Bioss
1 antibody
Bioworld Technology, Inc
1 antibody
Arigo
2 antibodies
Affinity Biosciences
3 antibodies
ProSci
4 antibodies
Bethyl Laboratories
2 antibodies
ABEOMICS Inc.
2 antibodies
Boster Biological Technology
2 antibodies
St John's Laboratory
3 antibodies
Creative Diagnostics
7 antibodies
Antibodies.com
1 antibody
Cell Signaling Technology, Inc
1 antibody
Everest Biotech
1 antibody
RabMAbs
1 antibody
MyBioSource
10 antibodies
Atlas Antibodies
1 antibody
United States Biological
43 antibodies
Abbiotec
3 antibodies
RayBiotech, Inc.
5 antibodies
BioLegend
4 antibodies
Sigma-Aldrich
4 antibodies
GenWay
2 antibodies
Active Motif
1 antibody
EMD Millipore
1 antibody