LMX1A

This gene encodes a homeodomain and LIM-domain containing protein. The encoded protein is a transcription factor that acts as a positive regulator of insulin gene transcription. This gene also plays a role in the development of dopamine producing neurons during embryogenesis. Mutations in this gene are associated with an increased risk of developing Parkinson's disease. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]

Description

LIM homeobox transcription factor 1 alpha

Protein family

Mapped to neXtProt, Mapped to UniProt SWISS-PROT, Predicted intracellular proteins, Transcription factors

Chromosome

1:q23.3 (165201867 - 165356715)

Ensembl ID

ENSG00000162761  (ver. 99.38)

Orthologs

Mouse Lmx1a: ENSMUSG00000026686

UniProt

Q8TE12

neXtProt

NX_Q8TE12

Human splice variants
Mouse splice variants