Antibody data
- Antibody Data
- Antigen structure
- References [3]
- Comments [0]
- Validations
- Western blot [2]
- Immunohistochemistry [5]
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Validation data
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- Product number
- NBP1-85790 - Provider product page
- Provider
- Novus Biologicals
- Proper citation
- Novus Cat#NBP1-85790, RRID:AB_11039132
- Product name
- Rabbit Polyclonal Ketohexokinase Antibody
- Antibody type
- Polyclonal
- Description
- Immunogen affinity purified. Specificity of human Ketohexokinase antibody verified on a Protein Array containing target protein plus 383 other non-specific proteins.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 0.1 ml
- Storage
- Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Submitted references HIF-driven SF3B1 induces KHK-C to enforce fructolysis and heart disease.
Endogenous fructose production and metabolism in the liver contributes to the development of metabolic syndrome.
Opposing effects of fructokinase C and A isoforms on fructose-induced metabolic syndrome in mice.
Mirtschink P, Krishnan J, Grimm F, Sarre A, Hörl M, Kayikci M, Fankhauser N, Christinat Y, Cortijo C, Feehan O, Vukolic A, Sossalla S, Stehr SN, Ule J, Zamboni N, Pedrazzini T, Krek W
Nature 2015 Jun 25;522(7557):444-449
Nature 2015 Jun 25;522(7557):444-449
Endogenous fructose production and metabolism in the liver contributes to the development of metabolic syndrome.
Lanaspa MA, Ishimoto T, Li N, Cicerchi C, Orlicky DJ, Ruzycki P, Rivard C, Inaba S, Roncal-Jimenez CA, Bales ES, Diggle CP, Asipu A, Petrash JM, Kosugi T, Maruyama S, Sanchez-Lozada LG, McManaman JL, Bonthron DT, Sautin YY, Johnson RJ
Nature communications 2013;4:2434
Nature communications 2013;4:2434
Opposing effects of fructokinase C and A isoforms on fructose-induced metabolic syndrome in mice.
Ishimoto T, Lanaspa MA, Le MT, Garcia GE, Diggle CP, Maclean PS, Jackman MR, Asipu A, Roncal-Jimenez CA, Kosugi T, Rivard CJ, Maruyama S, Rodriguez-Iturbe B, Sánchez-Lozada LG, Bonthron DT, Sautin YY, Johnson RJ
Proceedings of the National Academy of Sciences of the United States of America 2012 Mar 13;109(11):4320-5
Proceedings of the National Academy of Sciences of the United States of America 2012 Mar 13;109(11):4320-5
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: Ketohexokinase Antibody [NBP1-85790] - Analysis in human cell line HepG2.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: Ketohexokinase Antibody [NBP1-85790] - Western blot analysis in mouse liver tissue and rat liver tissue.
Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: Ketohexokinase Antibody [NBP1-85790] - Staining of human small intestine shows moderate cytoplasmic positivity in glandular cells.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: Ketohexokinase Antibody [NBP1-85790] - Staining of human kidney shows moderate cytoplasmic positivity in cells in tubules.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: Ketohexokinase Antibody [NBP1-85790] - Staining of human skeletal muscle shows no positivity in myocytes as expected.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: Ketohexokinase Antibody [NBP1-85790] - Staining of human liver shows moderate cytoplasmic positivity in hepatocytes.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: Ketohexokinase Antibody [NBP1-85790] - Staining in human small intestine and skeletal muscle tissues . Corresponding KHK RNA-seq data are presented for the same tissues.