HPA007040

antibody from Atlas Antibodies

Targeting: KHK

Provider product page for HPA007040

Western blot

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [16]
Comments [0]
Validations
Immunohistochemistry [1]

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Product number: HPA007040 - Provider product page
Provider: Atlas Antibodies
Proper citation: Atlas Antibodies Cat#HPA007040, RRID:AB_1079185
Product name: Anti-KHK
Antibody type: Polyclonal
Description: Polyclonal Antibody against Human KHK, Gene description: ketohexokinase (fructokinase), Validated applications: WB, IHC, Uniprot ID: P50053, Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 100 µl
Concentration: 0.1 mg/ml
Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C.
Handling: The antibody solution should be gently mixed before use.

KHK protein structure - HPA007040 shown in red.

Submitted references Fructose vs. glucose: modulating stem cell growth and function through sugar supplementation

Elsaid S, Wu X, Tee S
FEBS Open Bio 2024;14(8):1277-1290

Endogenous Fructose Production and Metabolism Drive Metabolic Dysregulation and Liver Disease in Mice with Hereditary Fructose Intolerance

Andres-Hernando A, Orlicky D, Kuwabara M, Cicerchi C, Pedler M, Petrash M, Johnson R, Tolan D, Lanaspa M
Nutrients 2023;15(20):4376

High Fructose Corn Syrup Accelerates Kidney Disease and Mortality in Obese Mice with Metabolic Syndrome

Andres-Hernando A, Orlicky D, Cicerchi C, Kuwabara M, Garcia G, Nakagawa T, Sanchez-Lozada L, Johnson R, Lanaspa M
Biomolecules 2023;13(5):780

Ketohexokinase-mediated fructose metabolism is lost in hepatocellular carcinoma and can be leveraged for metabolic imaging

Tee S, Kim N, Cullen Q, Eskandari R, Mamakhanyan A, Srouji R, Chirayil R, Jeong S, Shakiba M, Kastenhuber E, Chen S, Sigel C, Lowe S, Jarnagin W, Thompson C, Schietinger A, Keshari K
Science Advances 2022;8(14)

ATF4-dependent fructolysis fuels growth of glioblastoma multiforme

Chen C, Zhang Z, Liu C, Wang B, Liu P, Fang S, Yang F, You Y, Li X
Nature Communications 2022;13(1)

Vasopressin mediates fructose-induced metabolic syndrome by activating the V1b receptor

Andres-Hernando A, Jensen T, Kuwabara M, Orlicky D, Cicerchi C, Li N, Roncal-Jimenez C, Garcia G, Ishimoto T, Maclean P, Bjornstad P, Sanchez-Lozada L, Kanbay M, Nakagawa T, Johnson R, Lanaspa M
JCI Insight 2021;6(1)

Deletion of Fructokinase in the Liver or in the Intestine Reveals Differential Effects on Sugar-Induced Metabolic Dysfunction

Andres-Hernando A, Orlicky D, Kuwabara M, Ishimoto T, Nakagawa T, Johnson R, Lanaspa M
Cell Metabolism 2020;32(1):117-127.e3

Sugar causes obesity and metabolic syndrome in mice independently of sweet taste

Andres-Hernando A, Kuwabara M, Orlicky D, Vandenbeuch A, Cicerchi C, Kinnamon S, Finger T, Johnson R, Lanaspa M
American Journal of Physiology-Endocrinology and Metabolism 2020;319(2):E276-E290

Ketohexokinase C blockade ameliorates fructose-induced metabolic dysfunction in fructose-sensitive mice

Lanaspa M, Andres-Hernando A, Orlicky D, Cicerchi C, Jang C, Li N, Milagres T, Kuwabara M, Wempe M, Rabinowitz J, Johnson R, Tolan D
Journal of Clinical Investigation 2018;128(6):2226-2238

Protective role of fructokinase blockade in the pathogenesis of acute kidney injury in mice

Andres-Hernando A, Li N, Cicerchi C, Inaba S, Chen W, Roncal-Jimenez C, Le M, Wempe M, Milagres T, Ishimoto T, Fini M, Nakagawa T, Johnson R, Lanaspa M
Nature Communications 2017;8(1)

Effects of exogenous desmopressin on a model of heat stress nephropathy in mice

Roncal-Jimenez C, Milagres T, Andres-Hernando A, Kuwabara M, Jensen T, Song Z, Bjornstad P, Garcia G, Sato Y, Sanchez-Lozada L, Lanaspa M, Johnson R
American Journal of Physiology-Renal Physiology 2017;312(3):F418-F426

Divergent effects of glucose and fructose on hepatic lipogenesis and insulin signaling

Softic S, Gupta M, Wang G, Fujisaka S, O’Neill B, Rao T, Willoughby J, Harbison C, Fitzgerald K, Ilkayeva O, Newgard C, Cohen D, Kahn C
Journal of Clinical Investigation 2017;127(11):4059-4074

Aging-associated renal disease in mice is fructokinase dependent

Roncal-Jimenez C, Ishimoto T, Lanaspa M, Milagres T, Hernando A, Jensen T, Miyazaki M, Doke T, Hayasaki T, Nakagawa T, Marumaya S, Long D, Garcia G, Kuwabara M, Sánchez-Lozada L, Kang D, Johnson R
American Journal of Physiology-Renal Physiology 2016;311(4):F722-F730

HIF-driven SF3B1 induces KHK-C to enforce fructolysis and heart disease

Mirtschink P, Krishnan J, Grimm F, Sarre A, Hörl M, Kayikci M, Fankhauser N, Christinat Y, Cortijo C, Feehan O, Vukolic A, Sossalla S, Stehr S, Ule J, Zamboni N, Pedrazzini T, Krek W
Nature 2015;522(7557):444-449

Endogenous fructose production and metabolism in the liver contributes to the development of metabolic syndrome

Lanaspa M, Ishimoto T, Li N, Cicerchi C, Orlicky D, Ruzycki P, Rivard C, Inaba S, Roncal-Jimenez C, Bales E, Diggle C, Asipu A, Petrash J, Kosugi T, Maruyama S, Sanchez-Lozada L, McManaman J, Bonthron D, Sautin Y, Johnson R
Nature Communications 2013;4(1)

Opposing effects of fructokinase C and A isoforms on fructose-induced metabolic syndrome in mice

Ishimoto T, Lanaspa M, Le M, Garcia G, Diggle C, MacLean P, Jackman M, Asipu A, Roncal-Jimenez C, Kosugi T, Rivard C, Maruyama S, Rodriguez-Iturbe B, Sánchez-Lozada L, Bonthron D, Sautin Y, Johnson R
Proceedings of the National Academy of Sciences 2012;109(11):4320-4325

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Supportive validation

Submitted by: Atlas Antibodies (provider)
Enhanced method: Orthogonal validation
Main image
Experimental details: Immunohistochemistry analysis in human small intestine and skeletal muscle tissues using HPA007040 antibody. Corresponding KHK RNA-seq data are presented for the same tissues.
Sample type: Human
Protocol: Protocol
Orthogonal method: Orthogonal validation of protein expression using IHC by comparison to RNA-seq data of corresponding target in high and low expression tissues.

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