Tissue expression
Cell line expression
Protein structure
KIF14
Kinesin family member 14KIAA0042
This gene encodes a member of the kinesin-3 superfamily of microtubule motor proteins. These proteins are involved in numerous processes including vesicle transport, chromosome segregation, mitotic spindle formation, and cytokinesis. In human HeLa-S3 and 293T cells, this protein is localized to the cytoplasm during interphase, to the spindle poles and spindle microtubules during mitosis, and to the midbody during cytokinesis. An internal motor domain displays microtubule-dependent ATPase activity, consistent with its function as a microtubule motor protein. Knockdown of this gene results in failed cytokinesis with endoreplication, which results in multinucleated cells. This gene has been identified as a likely oncogene in breast, lung and ovarian cancers, as well as retinoblastomas and gliomas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]
Top validated antibodies |
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antibodies-online | ABIN151721 | 3 references | Polyclonal |
WB
ICC
IP
IHC |
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Invitrogen Antibodies | 26000-1-AP | Polyclonal |
WB
IP
IHC
OA |
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Novus Biologicals | NB100-243 | 2 references | Polyclonal |
WB
IP
IHC
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Proteintech Group | 26000-1-AP | Polyclonal |
WB
EL
IP
IHC |
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Bethyl Laboratories | A300-912A | Polyclonal |
WB
ICC
IP
IHC |
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Supportive data in Antibodypedia
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Recommended by provider