Tissue expression
Cell line expression
Protein structure

MAP3K4

Mitogen-activated protein kinase kinase kinase 4
KIAA0213, MAPKKK4, MEKK4, MTK1 
The central core of each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of 3 protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which then activates a specific MAPK. While the ERK MAPKs are activated by mitogenic stimulation, the CSBP2 and JNK MAPKs are activated by environmental stresses such as osmotic shock, UV irradiation, wound stress, and inflammatory factors. This gene encodes a MAPKKK, the MEKK4 protein, also called MTK1. This protein contains a protein kinase catalytic domain at the C terminus. The N-terminal nonkinase domain may contain a regulatory domain. Expression of MEKK4 in mammalian cells activated the CSBP2 and JNK MAPK pathways, but not the ERK pathway. In vitro kinase studies indicated that recombinant MEKK4 can specifically phosphorylate and activate PRKMK6 and SERK1, MAPKKs that activate CSBP2 and JNK, respectively but cannot phosphorylate PRKMK1, an MAPKK that activates ERKs. MEKK4 is a major mediator of environmental stresses that activate the CSBP2 MAPK pathway, and a minor mediator of the JNK pathway. Several alternatively spliced transcripts encoding distinct isoforms have been described. [provided by RefSeq, May 2014]
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334 antibodies from 35 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
antibodies-online
90 antibodies
Novus Biologicals
7 antibodies
Invitrogen Antibodies
22 antibodies
Abnova Corporation
8 antibodies
Proteintech Group
2 antibodies
GeneTex
1 antibody
Signalway Antibody LLC
1 antibody
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3 antibodies
Abgent
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Affinity Biosciences
1 antibody
FineTest Biotech
1 antibody
St John's Laboratory
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Aviva Systems Biology
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Acris Antibodies GmbH
1 antibody
Atlas Antibodies
1 antibody
Cusabio Biotech Co., Ltd
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FabGennix
3 antibodies
RabMAbs
2 antibodies
Bethyl Laboratories
1 antibody
MilliporeSigma / Merck KGaA
3 antibodies
Bioworld Technology, Inc
1 antibody
NSJ Bioreagents
1 antibody
ProSci
1 antibody
Creative Biolabs
12 antibodies
Creative Diagnostics
5 antibodies
Boster Biological Technology
2 antibodies
MyBioSource
5 antibodies
Abiocode, Inc.
1 antibody
United States Biological
82 antibodies
Abbexa
10 antibodies
Leading Biology
3 antibodies
Abbkine Scientific Co.Ltd.
1 antibody
RayBiotech, Inc.
1 antibody