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Learn14945-1-AP
antibody from Proteintech Group
Targeting: MAP3K20
MLK7, MLTK, MLTKalpha, MLTKbeta, MRK, ZAK
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [6]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- 14945-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#14945-1-AP, RRID:AB_10642698
- Product name
- ZAK antibody
- Antibody type
- Polyclonal
- Description
- ZAK antibody (Cat. #14945-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Initiation of a ZAKα-dependent ribotoxic stress response by the innate immunity endoribonuclease RNase L.
Nitric oxide-induced ribosome collision activates ribosomal surveillance mechanisms.
Myofibrillar myopathy hallmarks associated with ZAK deficiency.
Ribosome stalling is a signal for metabolic regulation by the ribotoxic stress response.
Ribosome impairment regulates intestinal stem cell identity via ZAKɑ activation.
Cytoplasmic DNA sensing by KU complex in aged CD4(+) T cell potentiates T cell activation and aging-related autoimmune inflammation.
Xi J, Snieckute G, Martínez JF, Arendrup FSW, Asthana A, Gaughan C, Lund AH, Bekker-Jensen S, Silverman RH
Cell reports 2024 Apr 23;43(4):113998
Cell reports 2024 Apr 23;43(4):113998
Nitric oxide-induced ribosome collision activates ribosomal surveillance mechanisms.
Ryder L, Arendrup FS, Martínez JF, Snieckute G, Pecorari C, Shah RA, Lund AH, Blasius M, Bekker-Jensen S
Cell death & disease 2023 Jul 26;14(7):467
Cell death & disease 2023 Jul 26;14(7):467
Myofibrillar myopathy hallmarks associated with ZAK deficiency.
Stonadge A, Genzor AV, Russell A, Hamed MF, Romero N, Evans G, Pownall ME, Bekker-Jensen S, Blanco G
Human molecular genetics 2023 Aug 26;32(17):2751-2770
Human molecular genetics 2023 Aug 26;32(17):2751-2770
Ribosome stalling is a signal for metabolic regulation by the ribotoxic stress response.
Snieckute G, Genzor AV, Vind AC, Ryder L, Stoneley M, Chamois S, Dreos R, Nordgaard C, Sass F, Blasius M, López AR, Brynjólfsdóttir SH, Andersen KL, Willis AE, Frankel LB, Poulsen SS, Gatfield D, Gerhart-Hines Z, Clemmensen C, Bekker-Jensen S
Cell metabolism 2022 Dec 6;34(12):2036-2046.e8
Cell metabolism 2022 Dec 6;34(12):2036-2046.e8
Ribosome impairment regulates intestinal stem cell identity via ZAKɑ activation.
Silva J, Alkan F, Ramalho S, Snieckute G, Prekovic S, Garcia AK, Hernández-Pérez S, van der Kammen R, Barnum D, Hoekman L, Altelaar M, Zwart W, Suijkerbuijk SJE, Bekker-Jensen S, Faller WJ
Nature communications 2022 Aug 2;13(1):4492
Nature communications 2022 Aug 2;13(1):4492
Cytoplasmic DNA sensing by KU complex in aged CD4(+) T cell potentiates T cell activation and aging-related autoimmune inflammation.
Wang Y, Fu Z, Li X, Liang Y, Pei S, Hao S, Zhu Q, Yu T, Pei Y, Yuan J, Ye J, Fu J, Xu J, Hong J, Yang R, Hou H, Huang X, Peng C, Zheng M, Xiao Y
Immunity 2021 Apr 13;54(4):632-647.e9
Immunity 2021 Apr 13;54(4):632-647.e9
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HepG2 cells were subjected to SDS PAGE followed by western blot with 14945-1-AP(ZAK antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The ZAK antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human ZAK. This antibody recognizes human,mouse,rat antigen. The ZAK antibody has been validated for the following applications: ELISA, WB, IHC analysis.
