Tissue expression
Cell line expression
Protein structure
MAP3K20
Mitogen-activated protein kinase kinase kinase 20MLK7, MLTK, MLTKalpha, MLTKbeta, MRK, ZAK
This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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antibodies-online | ![]() |
5 references | Monoclonal |
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Proteintech Group | ![]() |
6 references | Polyclonal |
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LSBio | ![]() |
Polyclonal |
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Novus Biologicals | ![]() |
1 references | Polyclonal |
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Abnova Corporation | ![]() |
2 references | Monoclonal |
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