DPABH-05750

antibody from Creative Diagnostics

Targeting: MDM4 HDMX, MDMX

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

DPABH-05750

Provider

Creative Diagnostics

Proper citation

Creative Diagnostics Cat#DPABH-05750, RRID:AB_2509449

Product name

Rabbit Anti-Human MDM4 Polyclonal Antibody

Antibody type

Polyclonal

Description

This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latters degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2011]

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

100 _L

Storage

Store at +4°C for short term storage. Long time storage is recommended at -20°C. Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user.