Tissue expression
Cell line expression

MDM4

gene product
HDMX, MDMX 
This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2011]
More gene data

Featured antibodies

Antibodies

 

Filters

Application

Validation method

Reference

Provider

Host

Reactivity

Antibody type

Conjugate

Antigen sequence

Epitope

Antibody

  or   Clear
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider
762 antibodies from 37 providers.

Antibody properties

Applications

or Cancel
AntibodyRefsTypeWBELICCIPIHCFC
antibodies-online
171 antibodies
Novus Biologicals
30 antibodies
Proteintech Group
1 antibody
OriGene
196 antibodies
LifeSpan BioSciences, Inc.
101 antibodies
GeneTex
6 antibodies
Biorbyt
22 antibodies
Acris Antibodies GmbH
4 antibodies
Abnova Corporation
10 antibodies
Invitrogen Antibodies
56 antibodies
Boster Biological Technology
4 antibodies
Affinity Biosciences
5 antibodies
Cusabio Biotech Co., Ltd
8 antibodies
Aviva Systems Biology
5 antibodies
Abgent
6 antibodies
Atlas Antibodies
2 antibodies
Bethyl Laboratories
5 antibodies
NovoPro Bioscience Inc.
2 antibodies
Wuhan Fine Biotech Co., Ltd.
1 antibody
ProSci
4 antibodies
Abbkine Scientific Co.Ltd.
2 antibodies
EMD Millipore
2 antibodies
NSJ Bioreagents
1 antibody
Creative Diagnostics
6 antibodies
MyBioSource
10 antibodies
Abbexa
14 antibodies
RayBiotech, Inc.
2 antibodies
Leading Biology
6 antibodies
MilliporeSigma / Merck KGaA
6 antibodies
Creative Biolabs
21 antibodies
Abbiotec
1 antibody
Abiocode, Inc.
1 antibody
Bioworld Technology, Inc
1 antibody
ChromoTek
1 antibody
United States Biological
32 antibodies
GenWay
2 antibodies