BS8157

antibody from Bioworld Technology, Inc
Targeting: C4BPB C4BP
Provider product page for BS8157
Western blot
Immunocytochemistry
Immunohistochemistry

Antibody data

Product number
BS8157 - Provider product page
Provider
Bioworld Technology, Inc
Product name
C4BPB polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human C4BPB.
Description
Complement component 4-binding protein (C4BP) is a plasma glycoprotein that inhibits the classical pathway of complement activation, which is mediated through antibody targeting of foreign antigen. Structurally, C4BP is a disulfide linked, multimeric protein that is composed of seven Ï« chains and one ÉÇ chain. C4BP functions as a cofactor for C3ÉÇ inactivator in the cleavage of C3ÉÇ, and accelerates the decay of C4ÉÇC2Ï« (C3 convertase) by acting as a cofactor in the cleavage of C4ÉÇ by factor I. Streptococcal strains that express Ig-binding cell surface molecules, which are members of the M protein family,can bind to overlapping C4ÉÇ binding sites in C4BP and therefore, interfere with the classical pathway of complement activation. Bacteria-bound C4BP may be an evolved mechanism that downregulates complement activation in the bacterial host microenvironment, thereby reducing the occurances of bacterial opsonization and phagocytosis.
Reactivity
Human
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
C4BPB protein structure - BS8157 shown in red.