Antibody data
- Antibody Data
- Antigen structure
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- Product number
- BS8157 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- C4BPB polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Recombinant full length Human C4BPB.
- Description
- Complement component 4-binding protein (C4BP) is a plasma glycoprotein that inhibits the classical pathway of complement activation, which is mediated through antibody targeting of foreign antigen. Structurally, C4BP is a disulfide linked, multimeric protein that is composed of seven Ï« chains and one ÉÇ chain. C4BP functions as a cofactor for C3ÉÇ inactivator in the cleavage of C3ÉÇ, and accelerates the decay of C4ÉÇC2Ï« (C3 convertase) by acting as a cofactor in the cleavage of C4ÉÇ by factor I. Streptococcal strains that express Ig-binding cell surface molecules, which are members of the M protein family,can bind to overlapping C4ÉÇ binding sites in C4BP and therefore, interfere with the classical pathway of complement activation. Bacteria-bound C4BP may be an evolved mechanism that downregulates complement activation in the bacterial host microenvironment, thereby reducing the occurances of bacterial opsonization and phagocytosis.
- Reactivity
- Human
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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