Antibody data
- Antibody Data
- Antigen structure
- References [4]
- Comments [0]
- Validations [0]
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- Product number
- ABIN116931 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-Left-Right Determination Factor 2 (LEFTY2) antibody
- Antibody type
- Monoclonal
- Antigen
- A BALB/c mouse was immunized with a recombinant form of 6X HIS tagged human LEFTY.
- Reactivity
- Human, Mouse, Rat
- Host
- Mouse
- Isotype
- IgG
- Antibody clone number
- 7C5G1H6H10
- Vial size
- 0.1 mg
- Concentration
- 1.0 mg/ml (by UV absorbance at 280 nm)
- Storage
- Store the antibody (undiluted) at 2-8°C for one month or (in aliquots) at -20°C for longer. Dilute only prior to immediate use. Avoid repeated freezing and thawing. Shelf life: One year from despatch.
Submitted references Lefty inhibits receptor-regulated Smad phosphorylation induced by the activated transforming growth factor-beta receptor.
Multiple left-right asymmetry defects in Shh(-/-) mutant mice unveil a convergence of the shh and retinoic acid pathways in the control of Lefty-1.
Randomization of left-right asymmetry due to loss of nodal cilia generating leftward flow of extraembryonic fluid in mice lacking KIF3B motor protein.
lefty-1 is required for left-right determination as a regulator of lefty-2 and nodal.
Ulloa L, Tabibzadeh S
The Journal of biological chemistry 2001 Jun 15;276(24):21397-404
The Journal of biological chemistry 2001 Jun 15;276(24):21397-404
Multiple left-right asymmetry defects in Shh(-/-) mutant mice unveil a convergence of the shh and retinoic acid pathways in the control of Lefty-1.
Tsukui T, Capdevila J, Tamura K, Ruiz-Lozano P, Rodriguez-Esteban C, Yonei-Tamura S, Magallón J, Chandraratna RA, Chien K, Blumberg B, Evans RM, Belmonte JC
Proceedings of the National Academy of Sciences of the United States of America 1999 Sep 28;96(20):11376-81
Proceedings of the National Academy of Sciences of the United States of America 1999 Sep 28;96(20):11376-81
Randomization of left-right asymmetry due to loss of nodal cilia generating leftward flow of extraembryonic fluid in mice lacking KIF3B motor protein.
Nonaka S, Tanaka Y, Okada Y, Takeda S, Harada A, Kanai Y, Kido M, Hirokawa N
Cell 1998 Dec 11;95(6):829-37
Cell 1998 Dec 11;95(6):829-37
lefty-1 is required for left-right determination as a regulator of lefty-2 and nodal.
Meno C, Shimono A, Saijoh Y, Yashiro K, Mochida K, Ohishi S, Noji S, Kondoh H, Hamada H
Cell 1998 Aug 7;94(3):287-97
Cell 1998 Aug 7;94(3):287-97
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