TAF5L

The product of this gene belongs to the WD-repeat TAF5 family of proteins. This gene encodes a protein that is a component of the PCAF histone acetylase complex. The PCAF histone acetylase complex, which is composed of more than 20 polypeptides some of which are TAFs, is required for myogenic transcription and differentiation. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors to facilitate complex assembly and transcription initiation. The encoded protein is structurally similar to one of the histone-like TAFs, TAF5. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Description

TATA-box binding protein associated factor 5 like

Tissue specificity

Low tissue specificity

Subcell location

Nuclear speckles, Cytoplasmic bodies

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

1 (229593121 - 229626047)

Ensembl ID

ENSG00000135801  (ver. 103.38)

Orthologs

Mouse Taf5l: ENSMUSG00000038697

UniProt

O75529

neXtProt

NX_O75529

Human splice variants
Mouse splice variants

Protein structure