EXOC8

This gene encodes a component of the exocyst complex, an evolutionarily conserved multi-protein complex that plays a critical role in vesicular trafficking and the secretory pathway by targeting post-Golgi vesicles to the plasma membrane. This protein is a target of activated Ral subfamily of GTPases and thereby regulates exocytosis by tethering vesicles to the plasma membrane. Mutations in this gene may be related to Joubert syndrome. [provided by RefSeq, Sep 2016]

Description

exocyst complex component 8

Protein family

Mapped to neXtProt, Mapped to UniProt SWISS-PROT, Predicted intracellular proteins, Protein evidence (Peptideatlas), Transporters

Chromosome

1:q42.2 (231332753 - 231337852)

Ensembl ID

ENSG00000116903  (ver. 99.38)

Orthologs

Mouse Exoc8: ENSMUSG00000074030

UniProt

Q8IYI6

neXtProt

NX_Q8IYI6

Human splice variants
Mouse splice variants